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Completed

NCT Number: NCT06978101

Visual Field Changes and OCT Angiographic Chorioretinal Changes in Patients With Primary Open Angle Glaucoma

This study aimed to assess the correlation between visual field changes and optical coherence tomography (OCT) angiography changes of retinal nerve fiber layer in patients with primary open angle glaucoma.

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Key information

Conditions

Visual Field Chorioretinal Changes Eye Diseases Glaucoma Glaucoma, Open-Angle OCT Angiography Ocular Hypertension Primary Open Angle Glaucoma

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Assiut university

Asyut, 71515, Egypt

About this study

Glaucoma is the leading cause of irreversible blindness worldwide. Since glaucomatous damage is preventable but irreversible, an early diagnosis and close follow-up of glaucoma patients are primordial. Optical coherence tomography angiography (OCTA) is a recently developed, noninvasive imaging modality that detects blood flow through the motion contrast generated by red blood cells.

Currently, there are 2 groups of complementary exams used for the diagnosis and follow-up of glaucoma patients: structural (where OCT has a considerable role) and functional (visual field) optic nerve measurements, Both technologies have strengths and limitations.

A new technology for diagnosis and follow-up that can avoid the limitations summarized above is lacking. OCTA seems to be a good candidate for such a role, OCT can detect the Doppler frequency shift of the backscattered light that provides information on blood flow.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Primary open angle glaucoma patients.

Exclusion criteria

  • Hazy media.
  • Diabetic Retinopathy.
  • Uveitis.
  • Other Glaucomas
  • Acute congestive glaucoma
  • Secondary glaucomas

Treatment and study plan

POAG group

Other

Patients had intraocular pressure (IOP)>21 mmHg.

Control Group

Other

Patients without family history of primary open-angle glaucoma (POAG), IOP ˂21mm Hg.

Primary outcomes

  1. Peripapillary vessel density (PpVD)

    Time frame: 12 months post-procedure

    Peripapillary vessel density (PpVD) was examined with swept-source OCT(DRI OCT Triton;Topcon Corporation,Tokyo,Japan) after pupillary dilatation , using an optic disc scan , peripapillary vessel density was derived from the images acquired with a 6 mm x6 mm mm field of view centered on the optic disc.

    PpVD measurements were calculated within the RNFL in a slab from the internal limiting membrane (ILM) to the RNFL posterior boundary.

Secondary outcomes

  1. Pattern standard deviation (PSD)

    Time frame: 12 months post-procedure

    Pattern standard deviation ( PSD) on Visual field test was performed with the Swedish Interactive Threshold Algorithm (SITA) Standard strategy program 24-2 of the octopus polar analysis which measures 24 degrees temporally and 30 degrees nasally and test 54 points.

  2. Mean deviation (MD)

    Time frame: 12 months post-procedure

    Mean deviation(MD) on Visual field test was performed with the Swedish Interactive Threshold Algorithm (SITA) Standard strategy program 24-2 of the octopus polar analysis which measures 24 degrees temporally and 30 degrees nasally and test 54 points.

  3. The thickness of the peripapillary retinal nerve fiber layer(RNFL)

    Time frame: 12 months post-procedure

    The thickness of the peripapillary retinal nerve fiber layer(RNFL) was obtained from a circle with a diameter of 3.4 mm centered on the optic disc.

    The RNFL thickness in 4 quadrants and 12 clock-hour were obtained by using the built-in automated segmentation algorism of the system.

  4. Intraocular pressure (IOP)

    Time frame: 12 months post-procedure

    Intraocular pressure (IOP) was recorded.

Sponsors and collaborators

Lead sponsor

Assiut University

Other

Registry information

Official study title

Correlation Between Visual Field Changes and OCT Angiographic Chorioretinal Changes in Patients With Primary Open Angle Glaucoma

Important dates

Study start
2021
Primary completion
2023
Study completion
2023
First posted
May 18, 2025
Registry last updated
May 18, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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