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NCT Number: NCT01021982

Evaluation of Objective Perimetry Using Pupillometer

Objective perimetry can better monitor visual field defects in RP and Glaucoma patients than conventional subjective perimetry.The PLR ( Pupil Light Reflex ) of the short and long wave ratio should be significantly higher in areas of visual field defects in RP and Glaucoma patients.

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Key information

Conditions

Retinitis Pigmentosa Congenital, Hereditary, and Neonatal Diseases and Abnormalities Eye Diseases Eye Diseases, Hereditary Genetic Diseases, Inborn Glaucoma Ocular Hypertension Retinal Degeneration Retinal Diseases Retinal Dystrophies Visual Field

Age range

18 year–75 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Sheba Medical Center

Tel Litwinsky, Israel, 52621

About this study

Pupil light reflex will be measured by a pupillometer in response to short and long wavelength light small spot stimulus in different area of the visual field. The PRL will be measured in four quadrant, central, 10, 20, and 30 degree from the visual axis.

Stimulus duration will be 1000 ms (1 sec), with intervals of 890 ms between stimuli. The stimuli size V with light intensity of 39.8 cd-s/m2 for both short wavelength stimuli (peak 485 nm) and long wavelength stimuli (peak 620nm).

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age 18-75
  • Sign on informed consent
  • Papillary response to light.
  • Groups of : Normal , Glaucoma patients with early glaucoma damage on HVF (nasal step ect. ), Glaucoma patients with advanced glaucoma damage on HVF (arcuate , tubular vision ) and RP patients (Early VF damage , ring scotoma ) .
  • Refractive correction up to -3.5 D.

Exclusion criteria

  • Cloudy corneas.
  • Surgical intraocular ophthalmic procedure within the past 30 days.
  • Nonreactive pupils.
  • Synechia of the iris to the lens after surgery or inflammation .
  • Neovascularization.
  • Iris coloboma.
  • Sphincter damage due to ischemia or trauma (tears of sphincter or diffuse damage to muscle).
  • Sphincter damage due to high intraocular pressure .
  • Iris tumor or cyst .
  • Ectropion uvea .
  • Adie's pupil .
  • Optic neuropathy with the potential for producing a positive RAPD (Relative Afferent Pupillary Defect ).
  • Chronic use of myotics or mydriatics.
  • Systemic Medication which affect on papillary response .
  • Any condition preventing accurate measurement or examination of the pupils.

Treatment and study plan

Primary outcomes

  1. PLR response amplitude and latency

    Time frame: Not defined yet

Sponsors and collaborators

Lead sponsor

Sheba Medical Center

Other Gov

Collaborators

  • Tel Aviv University, Claire and Amedee Maratier Institute

Registry information

Official study title

Objective Perimetry in Normal Subjects,Glaucoma Patients and Retinitis Pigmentosa Patients .

Important dates

Study start
2009
Primary completion
2013
Study completion
2013
First posted
Dec 1, 2009
Registry last updated
Nov 19, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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