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NCT Number: NCT07525713

Virtual Reality Mirror Therapy With Focused Object-Directed Attention System

In this study, the investigators hypothesized that Virtual Reality Mirror Therapy with Focused Object-Directed Attention (VRMTFOA) would yield superior therapeutic effects compared to conventional Virtual Reality Mirror Therapy (VRMT) in individuals with unilateral stroke.

The aim of this study is to compare the immediate effects of a single session of VRMT, VRMTFOA, and VRMTFOA with auditory feedback on upper extremity function and brain activity in stroke patients.

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Key information

Conditions

Stroke Attention Brain Diseases Cardiovascular Diseases Central Nervous System Diseases Cerebrovascular Disorders Mirror Movement Therapy Nervous System Diseases Rehabilitation Task Performance Vascular Diseases Virtual Reality

Age range

20 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

National Cheng-Kung University Hospital

Tainan, Taiwan, 704

Location status: Recruiting

Location contact

Hsiu-Yun Hsu

CONTACT

[email protected]

886-6-2353535 ext. 2669

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Clinical diagnosis of stroke with unilateral side involved;
  • A score of Mini-mental state examination greater than 24 for proving higher mental function;
  • Time of onset > 6 months before treatment begins;
  • Premorbid right-handedness.

Exclusion criteria

  • Severe vision impairment;
  • Major cognitive-perceptual deficit;
  • Other brain disease.

Treatment and study plan

Task-Oriented Training

Other

Virtual Reality Mirror Therapy combined with Motor training targeted to goals that are relevant to the functional needs of the patient

Primary outcomes

  1. Change in the result of Fugl-Meyer assessment (FMA) for motor function of upper extremity test

    Time frame: baseline, 9 weeks and 21 weeks

    Each item is rated on a three-point ordinal scale (2 points for the detail being performed completely, 1 point for the detail being performed partially, and 0 for the detail not being performed). The maximum motor performance score is 66 points for the upper extremity.

Secondary outcomes

  1. Change in the result of Modified Ashworth scale (MAS)

    Time frame: baseline, 9 weeks and 21 weeks

    Muscle tone is defined by assess muscle tone by evaluating resistance to passive stretch, reflecting the level of spasticity, with scores ranging from 0 (no increase in tone) to 4 (rigidity in flexion or extension).

  2. Change in the result of Box and blocks test

    Time frame: baseline, 9 weeks and 21 weeks

    The score is the number of blocks carried from one box to the other in one minute. Higher values represent a better outcome.

  3. Change in the result of Semmes-Weinstein monofilament (SWM) test

    Time frame: baseline, 9 weeks and 21 weeks

    The Semmes-Weinstein monofilamenttest examines the cutaneous pressure threshold, range from 1.65-6.65. Higher values represent a worse outcome.

  4. Change in the result of Motor Activity Log

    Time frame: baseline, 9 weeks and 21 weeks

    Semi-structured interview examine how much and how well the subject uses their more-affected arm for 30 ADLs. Score range from 0-5. Higher values represent a better outcome.

  5. Surface electromyography (sEMG)

    Time frame: baseline, 9 weeks

    Change in the root mean square (RMS) of the EMG signal was computed to quantify the change of muscle activation.

  6. Clinical Global Impression (CGI) scale

    Time frame: 9 weeks

    Assess overall clinical change, rated on a 7-point scale ranging from 1 (very much improved) to 7 (very much worse).

Study contacts

Contact information is provided by the study sponsor or research team.

Hsiu-Yun Hsu, Ph.D

CONTACT

[email protected]

886-6-2353535 ext. 2669

Sponsors and collaborators

Lead sponsor

National Cheng-Kung University Hospital

Other

Registry information

Official study title

Virtual Reality Mirror Therapy With Focused Object-Directed Attention for Neuro-Rehabilitation

Important dates

Study start
2026
Primary completion
2027
Study completion
2027
First posted
Apr 13, 2026
Registry last updated
Jun 16, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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