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NCT Number: NCT07139379

Effects of Virtual Reality Multisensory Cooperative Task-Oriented Mirror Therapy

In the proposed study, the investigators assumed that Virtual Reality-Based Generative Bimanual Cooperative Task-Oriented Therapy (VRMCTOMT) will provide a better treatment effects than traditional virtual reality mirror therapy (VRMT) for the patients with unilateral stroke. The aim of the study is to examine the difference in the treatment effects among the combination of task-oriented training with either VRMCTOMT, or VRMT on the upper extremity function and brain activity of the stroke patients.

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Key information

Conditions

Stroke Brain Diseases Cardiovascular Diseases Central Nervous System Diseases Cerebrovascular Disorders Mirror Movement Therapy Nervous System Diseases Rehabilitation Task Performance Vascular Diseases Virtual Reality

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

National Cheng-Kung University Hospital

Tainan, Taiwan, 704

Location status: Recruiting

Location contact

Hsiu-Yun Hsu

CONTACT

[email protected]

886-6-2353535 ext. 2669

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Clinical diagnosis of stroke with unilateral side involved;
  • A score of Mini-mental state examination greater than 24 for proving higher mental function
  • Time of onset > 6 months before treatment begins; and
  • Premorbid right-handedness.

Exclusion criteria

  • Severe vision impairment;
  • Major cognitive-perceptual deficit;
  • Other brain disease.

Treatment and study plan

Task-Oriented Training

Other

Motor training targeted to goals that are relevant to the functional needs of the patient

Virtual Reality Mirror Therapy

Other

Virtual Reality Mirror Therapy using goggle

Virtual Reality-Based Generative Bimanual Cooperative Task-Oriented Mirror Therapy

Other

Virtual Reality-Based Generative Bimanual Cooperative Task-Oriented Mirror Therapy using goggle

Primary outcomes

  1. Change in the result of Fugl-Meyer assessment (FMA) for motor function of upper extremity test

    Time frame: baseline, 9 weeks and 21 weeks

    Each item is rated on a three-point ordinal scale (2 points for the detail being performed completely, 1 point for the detail being performed partially, and 0 for the detail not being performed). The maximum motor performance score is 66 points for the upper extremity.

Secondary outcomes

  1. Change in the result of Modified Ashworth scale (MAS)

    Time frame: baseline, 9 weeks and 21 weeks

    Muscle tone is defined by assess muscle tone by evaluating resistance to passive stretch, reflecting the level of spasticity, with scores ranging from 0 (no increase in tone) to 4 (rigidity in flexion or extension).

Other outcomes

  1. Change in the result of Box and blocks test

    Time frame: baseline, 9 weeks and 21 weeks

    The score is the number of blocks carried from one box to the other in one minute. Higher values represent a better outcome.

  2. Change in the result of Semmes-Weinstein monofilament (SWM) test

    Time frame: baseline, 9 weeks and 21 weeks

    The Semmes-Weinstein monofilamenttest examines the cutaneous pressure threshold, range from 1.65-6.65. Higher values represent a worse outcome.

  3. Change in the result of Motor Activity Log

    Time frame: baseline, 9 weeks and 21 weeks

    Semi-structured interview examine how much and how well the subject uses their more-affected arm for 30 ADLs. Score range from 0-5. Higher values represent a better outcome.

  4. functional Magnetic Resonance Imaging

    Time frame: baseline, 9 weeks

    a non-invasive neuroimaging technique that measures brain activity by detecting changes in blood oxygenation (BOLD signal).

Study contacts

Contact information is provided by the study sponsor or research team.

Hsiu-Yun Hsu, Ph.D

CONTACT

[email protected]

886-6-2353535 ext. 2669

Sponsors and collaborators

Lead sponsor

National Cheng-Kung University Hospital

Other

Registry information

Official study title

Virtual Reality Multisensory Cooperative Task-Oriented Mirror Therapy for Neuro-Rehabilitation

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Aug 24, 2025
Registry last updated
Apr 15, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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