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NCT Number: NCT06866535

VIP - Vascular Infection Project

Constitution of a prospective multicentric observational database to study vascular infections, both native, especially aortitis, and vascular graft and endograft infections. Clinical and paraclinical data on medical, surgical, anesthetic and intensive care management will be collected in order to better characterize these infections

Recruiting

Interested in participating?

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Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

About this study

Vascular infections are rare but severe, burdened by high morbi-mortality and recurrence rates. However, many questions remain regarding their management which is still not consensual, both surgical and medical management. The term "vascular infections" encompasses vascular graft and endograft infections, as well as infections of native arteries and the aorta. For vascular graft infections, the optimal surgery is to remove the infected graft before vascular reconstruction with a new graft, either synthetic or biologic. However, some patients are too fragile to undergo surgery and might then benefit from an endovascular graft, an abscess drainage or no surgery at all, only medical treatment. For native arterial infections, surgery is often required to remove the infected arterial wall before vascular reconstruction. However, some patients cannot be operated on and might also benefit from an endovascular surgery. In these two vascular infections, the ideal anti-microbial treatment is uncertain, whether it pertains to the duration of therapy, the type of molecules, or their number. All of these medical and surgical factors may impact the prognosis of patients and should be collectively assessed in order to determine the best strategy for enhancing their outcomes.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • ≥ 18 years-old;
  • all patients with a vascular infection, either native (aortitis, arteritis) or prosthetic (vascular graft, endograft and/or stent),
  • oral consent

Exclusion criteria

  • patient under legal protection

Treatment and study plan

Primary outcomes

  1. mortality

    Time frame: Year 1

    mortality r

Secondary outcomes

  1. mortality

    Time frame: Day 30, Year 2, Year 5

    mortality rate

  2. morbidity

    Time frame: Year 1

    morbidity rate

  3. relapse

    Time frame: year 1, Year 2, Year 5

    relapse rates

  4. reinfection

    Time frame: year 1, Year 2, Year 5

    reinfection rates

Study contacts

Contact information is provided by the study sponsor or research team.

Mathilde Puges, MD

CONTACT

[email protected]

+335 56 79 55 36

Sponsors and collaborators

Lead sponsor

University Hospital, Bordeaux

Other

Registry information

Official study title

VIP - Vascular Infection Project : Prospective Multicentric Database on Vascular Infections

Acronym: Cohorte VIP

Important dates

Study start
2022
Primary completion
2032
Study completion
2032
First posted
Mar 10, 2025
Registry last updated
Mar 10, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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