VCRC Tissue Repository

The purpose of this study is to collect existing tissue specimens from subjects enrolled in Vasculitis Clinical Research Consortium (VCRC) studies. Analysis of these tissue specimens and linked clinical data collected through VCRC studies may lead to the identification and development of a series of translational research projects. Results of these studies will provide vasculitis researchers with insight into the causes of these diseases and generate new ideas for diagnostic tests and therapies, and will be of great interest to the larger communities of researchers investigating vasculitis and other autoimmune, inflammatory, and vascular diseases.

Recruiting

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Key information

Conditions

Aortitis Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis Aortic Arch Syndromes Aortic Diseases Arteritis Autoimmune Diseases Autoimmune Diseases of the Nervous System Blood Coagulation Disorders Brain Diseases Cardiovascular Diseases Central Nervous System Diseases Cerebral Small Vessel Diseases Cerebrovascular Disorders Churg-Strauss Syndrome Cutaneous Vasculitis Eosinophilic Granulomatosis With Polyangiitis Giant Cell Arteritis Granuloma Granulomatosis With Polyangiitis (Wegener's) Granulomatosis with Polyangiitis Hematologic Diseases Hemic and Lymphatic Diseases Hemorrhage Hemorrhagic Disorders Hemostatic Disorders Henoch-Schonlein Purpura Hypersensitivity IgA Vasculitis Immune Complex Diseases Immune System Diseases Lung Diseases Lung Diseases, Interstitial Lymphatic Diseases Lymphoproliferative Disorders Microscopic Polyangiitis Nervous System Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Polyarteritis Nodosa Purpura Respiratory Tract Diseases Signs and Symptoms Skin Diseases Skin Diseases, Vascular Skin Manifestations Skin and Connective Tissue Diseases Systemic Vasculitis Takayasu Arteritis Vascular Diseases Vasculitis Vasculitis, Central Nervous System

Sex eligibility

All sexes

Study type

Observational

Primary location

St. Joseph's Healthcare, Hamilton, Ontario, Canada

About this study

Biopsy specimens collected as standard of care for these diseases will be retrieved and used in research. The most common biopsies performed are kidney, lung, skin, nerves, and vessels; however, other tissue is also of interest for the study. Biopsies are not performed as part of this protocol, rather we will request consent to collect biopsy specimens already collected under routine care.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

A participant will be deemed eligible for this study if the participant is/was enrolled in another one of the VCRC observational/longitudinal protocols (5502, 5503, 5504, 5505, 5506, 5507, 5563) and/or one of the VCRC interventional studies (5522, 5523, 5526, 5527, or 5562).

Exclusion criteria

Inability to give informed consent (or their guardians in the case of children) and to sign the consent form.
Unwilling to allow the use of their tissue for research.

Treatment and study plan

Primary outcomes

Identify genes that increase the risk of developing vasculitis

Time frame: 1 year

Evaluating of clinical data and linked biopsy specimens to identify genes that increase the risk of developing vasculitis.

Study contacts

Contact information is provided by the study sponsor or research team.

Katie Doyle

CONTACT

[email protected]

Sponsors and collaborators

Lead sponsor

University of Pennsylvania

Other

Collaborators

National Center for Advancing Translational Sciences (NCATS)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Office of Rare Diseases (ORD)

Registry information

Official study title

VCRC Tissue Biorepository Collection Protocol

Important dates

Study start: 2016
Primary completion: 2028
Study completion: 2028
First posted: Nov 17, 2016
Registry last updated: Jan 22, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed