Skip to main content
OpenTrials
Recruiting

NCT Number: NCT06824532

Veteran's Perceptions of Ketamine-Assisted Psychotherapy for Depression and End-of-Life

The goal of this exploratory, mixed-method design study is to gather qualitative and quantitative data obtained through interviews and questionnaires with veterans who are currently enrolled at the VA for healthcare. The main question this study aims to answer is: How do veterans aged 65+ who are enrolled for care at the VA understand ketamine assisted psychotherapy for depression and for end-of-life distress? Using a story-completion approach, participants will be provided with a brief story starter involving a fictitious character and scenario and asking them to complete the story. Few contextual details will be offered about the character. In responding to ambiguous cues, participants are thought to project their conscious and subconscious perceptions about the phenomenon in question onto the story, a useful method for exploring stigmatized topics. The purpose of this exercise is to ascertain the participants attitudes and perceptions regarding ketamine assisted psychotherapy.

Recruiting

Interested in participating?

Request Info

Key information

Age range

65 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Stratton VA Medical Center

Albany, New York, 12208, United States

Location status: Recruiting

Location contact

Caitlin Holley, Ph.D.

CONTACT

[email protected]

518-626-5365

About this study

Veterans will be informed of the study by their VA providers (Behavioral Health Clinic, Primary Care, etc). Veterans who are interested will have their contact information passed on to the study investigators. Once screened and enrolled in the study veterans will complete a brief demographics form, and three brief symptom screening questionnaires: Patient Health Questionnaire 9, Ten Item Personality Inventory, and the Death Anxiety Questionnaire. Participants then engage in the recorded interview during which they are provided with a brief story starter, as described above. In the story, a fictitious veteran with a diagnosis of depression is offered an opportunity to engage in ketamine assisted psychotherapy (KAP). The veteran then receives a cancer diagnosis and is again offered a chance to consider KAP. Participants are asked to share what questions, concerns, hopes, and expectations may be present for the fictitious veteran in the story. Interviews will then be transcribed and the PI and the collaborators will read all transcriptions and generate recurring themes that can be reliably coded. The investigators will then code the transcripts for the presence of themes. Data analytic plans include calculating the prevalence of each theme and examining their correlates with measures of severity of symptoms as well as any demographic variables. It is hoped that this data can inform educational and other roll-out efforts within the VA system around KAP.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Veterans enrolled in VA care.
  • Age 65 or older.
  • Fluent in written and spoken English.

Exclusion criteria

  • Cognitively impaired to the extent that patient cannot comprehend the survey.

Treatment and study plan

Primary outcomes

  1. Patient Health Questionnaire 9

    Time frame: 2 weeks

    Screening tool for depressive symptoms. Scores range from 0-27 with lower scores indicating better outcomes

  2. Ten Item Personality Inventory

    Time frame: 2 weeks

    A 10-item measure of the Big Five dimensions is offered for situations when very short measures are needed, personality is not the primary topic of interest. It assesses the big-five traits-Emotional Stability, Extraversion, Openness, Agreeableness, and Conscientiousness-using two items for each scale. Scores range from 1-70.

  3. Death Anxiety Questionnaire

    Time frame: 2 weeks

    The 15-item self report scale is a reliable and valid measure of individual differences in and perceptions of death anxiety. Scores range from 0-30 with higher scores indicate a higher level of anxiety.

Study contacts

Contact information is provided by the study sponsor or research team.

Caitlin Holley, Ph.D.

CONTACT

[email protected]

518-626-5365

Stacey Farmer, Ph.D.

CONTACT

[email protected]

518-798-6066

Sponsors and collaborators

Lead sponsor

Albany Research Institute, Inc.

Other

Registry information

Official study title

Veteran's Perceptions of Ketamine-Assisted Psychotherapy (KAP) for Depression and End-of-Life

Acronym: KAP

Important dates

Study start
2024
Primary completion
2025
Study completion
2025
First posted
Feb 13, 2025
Registry last updated
Feb 13, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.