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OpenTrials
Completed

NCT Number: NCT07364604

Very Early Outcomes in Endoscopic Versus Open Carpal Tunnel Release

We are looking at whether there is a difference in pain and function in the very early period when comparing carpal tunnel release performed by the endoscopic technique versus the open technique.

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Key information

Conditions

Carpal Tunnel Syndrome (CTS) Carpal Tunnel Syndrome Cumulative Trauma Disorders Median Neuropathy Mononeuropathies Nerve Compression Syndromes Nervous System Diseases Neuromuscular Diseases Peripheral Nervous System Diseases Sprains and Strains Wounds and Injuries

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Stanford University

Palo Alto, California, 93405, United States

About this study

The purpose of our study is to examine the very early (<2 weeks post-op) outcomes of endoscopic versus open carpal tunnel releases (CTR). We will call patients on post-operative days 3, 7 and 14 and collect Single Assessment Numeric Evaluation (SANE), Patient Related Wrist and Hand Evaluation (PRWHE), Visual Analog Scale (VAS) pain and return to work status at each time frame to see if there is any difference between the two procedures.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients 18 years of age or older
  • Diagnosed with carpal tunnel syndrome and indicated to undergo carpal tunnel release with one of the three participating hand surgeons were included in this study.

Exclusion criteria

  • Patients younger than 18 years old
  • Pregnant women
  • Revision carpal tunnel surgery, or patients who underwent any other type of surgery concomitantly with the carpal tunnel release.

Treatment and study plan

Carpal tunnel release

Procedure

Description: An open incision was made over the proximal palm to access and visualize transverse carpal tunnel, then divided it completely surgically. In the endoscopic technique, a small incision is made over the distal wrist and a camera and blade are within the wrist, then the transverse carpal ligament is divide from inside the palm

Primary outcomes

  1. Post-operative pain

    Time frame: This was assessed at post-operative days 3, 7, and 14

    This was evaluated by administering the Patient Related Wrist and Hand Evaluation (PRWHE) questionnaire as well as obtaining a pain score using the Visual Analog Scale (VAS).

  2. Function

    Time frame: Function was assessed at post-operative days 3, 7 and 14.

    Patients were first asked to assess the function of their operative hand and wrist using the Single Assessment Numeric Evaluation (SANE) tool. Function was also assessed by administering the Patient Related Wrist and Hand Evaluation (PRWHE) questionnaire.

Secondary outcomes

  1. Return to Work Status

    Time frame: Return to work status was assessed at post-operative days 3, 7, and 14.

    Of those study patients who were not retired, we assessed if and when patients returned to work.

Sponsors and collaborators

Lead sponsor

Stanford University

Other

Registry information

Important dates

Study start
2022
Primary completion
2024
Study completion
2024
First posted
Jan 23, 2026
Registry last updated
Jan 23, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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