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Completed

NCT Number: NCT07573878

Combined Effects of Neurodynamics With PNF on Pain and ROM in Patients With CTS.

The goal of this clinical trial is to determine the combined effects of neurodynamics with proprioceptive neuromuscular facilitation technique on reducing pain and improving range of motion in patients with carpal tunnel syndrome. This study evaluates whether neurodynamics combined with PNF is an effective approach in treating CTS compared to baseline treatment, as both techniques are well known for their individual effects. This treatment is given for 2 weeks, 5 days per week with 10 repetitions for each exercise.

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Key information

Conditions

Carpal Tunnel Syndrome (CTS) Carpal Tunnel Syndrome Cumulative Trauma Disorders Median Neuropathy Mononeuropathies Nerve Compression Syndromes Nervous System Diseases Neuromuscular Diseases Peripheral Nervous System Diseases Sprains and Strains Wounds and Injuries

Age range

20 year–40 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Bahawal Victoria Hospital

Chak Four Hundred Fifty-four, Punjab Province, 63100, Pakistan

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Diagnosed cases of carpal tunnel syndrome.
  • Patients having positive Tinel's test and Phalen's test.
  • Symptoms persisted for at least 4 weeks.
  • Availability and motivation of patients to participate in a 2-week program.

Exclusion criteria

  • Patient with contraindications to rehabilitation treatment.
  • Patients with a history of previous upper limb surgery.
  • Patient received steroid injection or have any systemic disease that can influence condition.

Treatment and study plan

Neurodynamic and PNF

Other

These 2 exercises were provided in 10 repetitions for 2 weeks (duration), 5 days per week (frequency).

i) PNF techniques used in carpal tunnel treatment includes

  • Rhythmic Initiation
  • Agonistic Reversals. ii) For Neurodynamic

(1) Distal nerve tension technique :Hand was placed in six different positions each position maintained for 7 second and have 5 repetitions for each step this is done in median nerve tension technique (2) nerve slide

Other names: Neurodynamic, Proprioceptive Neuromuscular Facilitation technique

Baseline treatment

Other

They were provided with common conservative physical therapy treatment for 2 weeks, 5 days per week, following carpal tunnel syndrome.

These treatments included use of a wrist splint, especially at night, along with 10-15 min of cold and ultrasound therapy. Medications like NSAIDs were given for 5 days.

Other names: medication, wrist splint, Ultrasound therapy, Cold therapy

Primary outcomes

  1. Quick DASH Questionnaire

    Time frame: 2nd week

    Changes from Baseline Quick DASH questionnaire (Quick Disabilities of the Arm, Shoulder, and Hand) is a concise version of the DASH questionnaire. It consists of 11 items, with each item scored from 1 (no difficulty) to 5 (unable to perform), assessing daily activities, pain, and social functioning, along with optional modules for work or sports/performing arts. The total score ranges from 0 to 100, where 0 indicates no disability and 100 indicates the most severe disability.

    Score Ranges:

    0-20: Minimal disability 21-40: Mild to moderate disability 41-60: Moderate to severe disability 61-100: Extreme disability The score is calculated by summing responses, dividing by the number of items (n), subtracting 1, and multiplying by 25.

  2. Visual Analog Scale

    Time frame: 2nd week

    The Visual Analog Scale (VAS) is a frequently utilized tool in clinical and research settings to measure subjective experiences like pain. It was first developed in 1921 by psychologists Mary H.S. Hayes and Donald G. Paterson as a "graphic rating" method for subjective assessments, later adopted and adapted for measuring pain and clinical symptoms in the 1960s. It consists of a 10 cm line where patients spot their pain intensity, from 0 "no pain" at one end to 10 "unbearable pain" at the other.

Sponsors and collaborators

Lead sponsor

Riphah International University

Other

Registry information

Official study title

Combined Effects of Neurodynamics With Proprioceptive Neuromuscular Facilitation Technique on Pain and Range of Motion in Patient With Carpal Tunnel Syndrome.

Important dates

Study start
2025
Primary completion
2025
Study completion
2025
First posted
May 7, 2026
Registry last updated
May 7, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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