Validation of the Concept of the Autoantibodies Directed Against the Neuropeptides Involved in Food Intake Regulation on the Incidental Cases of Eating Disorders

Eating disorders are a public health issue. It has been recently reported the importance of immune system modifications in eating disorders physiopathology, involving autoantibodies directed against neuropeptides regulating food intake. A recent study of laboratory INSERM 1073 showed the existence of an intestinal bacterial protein exhibiting structural similarities with α-MSH: ClpB. The autoAc directed against the latter also react with α-MSH because of these similarity of structures, thus leading to a potential digestive origin of these autoAc. To consolidate this new etiopathogenic assumption, a large clinical study is necessary with analysis of patients autoAc profiles. a monocentric study with inclusion of 240 patients over 2 years and 80 healthy volunteers is proposed.

This study should lead to the validation of the concept of the autoAc directed against the neuropeptides involved in food intake regulation. Nutritional modulations (probiotic, amino-acid…) could constitute an interesting therapeutic perspective in the future.

Inclusion criteria

Patients with eating disorders

• 18 Years and older
• first clinical visit in nutrition department of CHU de Rouen for eating disorders
• anorexia nervosa, hyperphagia or bulimia according to the classification DSM-V
• social security Affiliation
• Patient who signed the MEC approved informed consent

Volunteers

• 18 Years to 60 Years
• body mass index ≥ 18,5 kg/m2 and ≤ 24,9 kg/m2
• negative SCOFF test
• No active and history of eating disorders
• social security Affiliation
• volunteer who signed the MEC approved informed consent

Exclusion criteria

Patients with eating disorders

• No anorexia nervosa, hyperphagia or bulimia according to the classification DSM-V
• Adults under legal protection or under safeguard of justice or administrative decision
• Pregnancy

Volunteers

• Active or history of eating disorder
• Adults under legal protection or under safeguard of justice or administrative decision
• Pregnancy