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OpenTrials
Completed

NCT Number: NCT03347565

Brain Function in Adolescent Eating Disorders and Healthy Peers

This study of adolescent eating disorders (ED) will examine the association of temperament-based classifications, brain activation during incentive processing, and ED symptoms at time of scan and 1 year later to better understand the neurobiology and symptoms of ED. We will recruit 150 females currently ill with an ED and 50 controls ages 14-17 to investigate how temperaments reflecting greater inhibition, impulsivity, or effortful control correspond to 1) clinical symptoms and 2) the brain's response to anticipation and outcome of salient stimuli, and 3) by collecting follow-up clinical data one year later, identify how temperament-based subtypes predict ED symptom change (e.g., clinical prediction). Data collection will rely on a technology called functional magnetic resonance imaging (fMRI).

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Key information

Conditions

Eating Disorder Feeding and Eating Disorders Mental Disorders Pathological Conditions, Signs and Symptoms Signs and Symptoms Signs and Symptoms, Digestive

Age range

14 year–17 year

Sex eligibility

Female

Study type

Observational

Primary location

University of California San Diego

San Diego, California, 92121, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Female
  • Meet DSM-V criteria for an Eating Disorder or Never met criteria for an Eating disorder
  • Medically stable
  • Post-Pubertal (must have started menses, but subsequent loss of menses secondary to ED is fine).

Exclusion criteria

  • Psychotic illness/other mental illness requiring hospitalization
  • Current dependence on drugs or alcohol
  • Physical conditions known to influence eating or weight (e.g, diabetes mellitus, pregnancy).
  • On psychoactive medication
  • Organic brain syndromes, delirium, psychotic disorders, or intellectual disability
  • Neurological or medical disorders such as seizure disorder
  • Any contraindication to undergoing an MRI
  • Major depressive disorder
  • Left handed

Treatment and study plan

Primary outcomes

  1. Brain function

    Time frame: 1 year (fMRI Scan)

    Functional Magnetic Resonance imaging will be used to assess brain activation associated with inhibition, impulsivity, and control

Sponsors and collaborators

Lead sponsor

University of California, San Diego

Other

Registry information

Official study title

Neurocircuitry of Temperament and Motivated Behavior in Adolescent Eating Disorders

Important dates

Study start
2017
Primary completion
2024
Study completion
2026
First posted
Nov 20, 2017
Registry last updated
May 13, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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