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NCT Number: NCT07604753

Validation of the CIDI 5.0 Against the SCID-5 for Lifetime Mental Disorders

The World Health Organization Composite International Diagnostic Interview (CIDI) is a fully structured diagnostic tool designed for lay interviewers to assess the prevalence of mental and substance use disorders. Earlier versions, such as the CIDI 3.0, demonstrated acceptable individual-level concordance with clinical assessments based on DSM-IV criteria (Haro et al. 2006). The latest iteration (CIDI 5.0) has been updated to operationalize DSM-5 criteria.

Recent evidence from a large-scale, community-based national study in Qatar suggests that under DSM-5 criteria (Khaled et al. 2024), after recalibration, the CIDI 5.0 maintains high specificity (91.9% for MDD, 94.7% for GAD, and 85.5% for PTSD). Sensitivity suggested CIDI diagnoses aligned closely with clinical "gold standard" diagnoses (51.5% for MDD, 50.7% for GAD, and 77.3% for PTSD). Despite the evidence from Qatar, there remains a lack of evidence regarding the validity of the CIDI 5.0 in population-based studies.

Therefore, this study aims to evaluate the diagnostic validity of the CIDI 5.0 for Lifetime MDD, GAD, and PTSD, using the Structured Clinical Interview for DSM-5 (SCID-5) as the definitive clinical gold standard.

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Key information

Conditions

Major Depressive Disorder (MDD) Anxiety Disorders Depressive Disorder Depressive Disorder, Major Generalized Anxiety Disorder Generalized Anxiety Disorder (GAD) Mental Disorders Mood Disorders Posttraumatic Stress Disorder (PTSD) Stress Disorders, Post-Traumatic Stress Disorders, Traumatic Trauma and Stressor Related Disorders

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • All household members aged 18 years old and over are randomly sampled from the Census and Statistics Department List of Quarters
  • Live in the address sampled from the Census and Statistics Department List of Quarters
  • Reside in Hong Kong for at least six months in the past year
  • Able to read and communicate in Chinese or English
  • Without linguistic or cognitive difficulties

Exclusion criteria

  • Domestic workers

Treatment and study plan

CIDI-5

Diagnostic Test

The World Health Organization Composite International Diagnostic Interview-5th (CIDI-5) is a standardized diagnostic tool used to assess the prevalence of mental and substance use disorders over varying time frames (30 days, 12 months, and lifetime) based on the diagnostic criteria outlined in the Diagnostic and Statistical Manual of Mental Disorders 5th edition (DSM-5) and International Classification of Diseases 10th edition (ICD-10). Trained interviewers will administer selected modules from the Hong Kong version of the CIDI-5 in a computer-assisted personal interview to measure the outcomes. To validate the diagnoses in the CIDI-5 group, investigators will conduct clinical re-interviews of 3 selected CIDI-5 diagnoses: major depressive disorder (MDD), generalized anxiety disorder (GAD), and post-traumatic stress disorder (PTSD) using the Structured Clinician Interview for DSM-5 (SCID) by a trained mental health professional with previous experience using SCID.

Primary outcomes

  1. Depression

    Time frame: Immediately following intervention or recruitment

    The main outcome in this module is the lifetime prevalence of Major Depressive Disorder (MDD)

  2. Worry and Anxiety

    Time frame: Immediately following intervention or recruitment

    The main outcome in this module is the lifetime prevalence of Generalized Anxiety Disorder (GAD)

  3. Stressful Experiences

    Time frame: Immediately following intervention or recruitment

    The main outcome in this module is the lifetime prevalence of PTSD.

Study contacts

Contact information is provided by the study sponsor or research team.

Yoona Kim, PhD

CONTACT

[email protected]

+852 3917 9109

Sponsors and collaborators

Lead sponsor

The University of Hong Kong

Other

Registry information

Official study title

Validity of the World Health Organization CIDI 5.0 for Assessing Lifetime Prevalence of Mental Disorders: A Clinical Reappraisal Study Using the SCID-5

Important dates

Study start
2025
Primary completion
2028
Study completion
2028
First posted
May 22, 2026
Registry last updated
May 22, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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