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NCT Number: NCT06804525

LHC-CIDI-5 in Hong Kong

The World Health Organization Composite International Diagnostic Interview-5th (CIDI-5) is a standardized diagnostic tool used to assess the prevalence of mental and substance use disorders over varying time frames (30 days, 12 months, and lifetime) based on the diagnostic criteria outlined in the Diagnostic and Statistical Manual of Mental Disorders 5th edition (DSM-5) and International Classification of Diseases 10th edition (ICD-10). However, retrospective measurements like the CIDI-5 are susceptible to recall bias, especially for the lifetime experience, which can hinder the reporting accuracy with mental disorders.

To mitigate this issue, the life history calendar (LHC) was introduced as an aid to assist respondents in recalling the timing of life events, enhancing the ability of the CIDI-5 to measure the lifetime prevalence of mental disorders. The LHC is a grid structure with columns representing time units and rows representing life domains under study.

In a study conducted in Nepal, combining the CIDI-5 with the LHC resulted in a significant increase in the detection of mental disorders compared to using the CIDI-5 alone. This approach did not lead to an increase in false positives after clinical validation.

This experiment aims to adapt a Hong Kong version of the LHC based on the Nepalese model and evaluate the effectiveness of the LHC-assisted CIDI-5 (LHC-CIDI-5) compared to the CIDI-5 alone in assessing mental disorders.

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Key information

Conditions

Major Depressive Episode (MDE) Alcohol Use Disorder (AUD) Alcohol-Related Disorders Alcoholism Anxiety Disorders Behavior Behavioral Symptoms Bipolar Disorder Bipolar I Disorder Bipolar II Disorder Bipolar Sub Disorder Bipolar and Related Disorders Chemically-Induced Disorders Depressive Disorder Depressive Disorder, Major Disruptive, Impulse Control, and Conduct Disorders Generalized Anxiety Disorder Generalized Anxiety Disorder (GAD) Hypomanic Intermittent Explosive Disorder (IED) Major Depressive Disorder (MDD) Mania Manic Episode Mental Disorders Mood Disorders Nervous System Diseases Neurobehavioral Manifestations Neurologic Manifestations Nonsuicidal Self-Injury Obsessive-Compulsive Disorder Obsessive-Compulsive Disorder (OCD) PCL-5 PTSD PCL-SC PTSD Panic Attack Panic Disorder Pathological Conditions, Signs and Symptoms Persistent Depressive Disorder (PDD) Posttraumatic Stress Disorder (PTSD) Self-Injurious Behavior Signs and Symptoms Stress Disorders, Post-Traumatic Stress Disorders, Traumatic Substance Use Disorder (SUD) Substance-Related Disorders Suicidal Attempt Suicidal Gesture Suicidal Ideation Suicidal Plan Suicide Trauma and Stressor Related Disorders

Age range

25 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

The University of Hong Kong

Hong Kong

Location status: Recruiting

Location contact

Michael Y. Ni, MD

PRINCIPAL_INVESTIGATOR

Yoona Kim, PhD

CONTACT

[email protected]

852+39179109

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • All household members aged 25 years old and over are randomly sampled from the Census and Statistics Department List of Quarters
  • Live in the address sampled from the Census and Statistics Department List of Quarters
  • Reside in Hong Kong for at least six months in the past year
  • Able to read and communicate in Chinese or English
  • Without linguistic or cognitive difficulties

Exclusion criteria

  • Domestic workers

Treatment and study plan

CIDI-5

Diagnostic Test

The World Health Organization Composite International Diagnostic Interview-5th (CIDI-5) is a standardized diagnostic tool used to assess the prevalence of mental and substance use disorders over varying time frames (30 days, 12 months, and lifetime) based on the diagnostic criteria outlined in the Diagnostic and Statistical Manual of Mental Disorders 5th edition (DSM-5) and International Classification of Diseases 10th edition (ICD-10) . Trained interviewers will administrate selected modules from the Hong Kong version of the CIDI-5 in a computer-assisted personal interview to measure the outcomes.

LHC-CIDI-5

Diagnostic Test

The interviewer will start by asking the respondent's age and significant personal experiences, which is expected to take 15 minutes. Remembering and recording the experiences provide cognitive engagement and information which can further serve as memory cues for respondents in the following screening of CIDI-5. Subsequently, the respondents will proceed to the screening section for CIDI-5 and will refer to the completed calendar from the LHC section when they are asked to report lifetime experience or age-of-onset for mental disorders. Trained interviewers will conduct all interviews in a computer-assisted personal interview. To validate the diagnoses in the LHC-CIDI-5 group, clinical re-interviews for MDD, GAD, and PTSD will be conducted by a trained mental health professional with previous experience using DSM-5.

Primary outcomes

  1. Depression

    Time frame: Immediately following intervention or recruitment

    The main outcomes in this module are the lifetime prevalence of Major Depressive Episode (MDE) and Major Depressive Disorder (MDD)

  2. Persistent Depression

    Time frame: Immediately following intervention or recruitment

    The main outcome in this module is the lifetime prevalence of Persistent Depressive Disorder (PDD)

  3. Self Harm

    Time frame: Immediately following intervention or recruitment

    The main outcomes in this module are the lifetime prevalence of Suicidal Ideation, Suicidal Plan, Suicidal Attempt, Suicidal Gesture, and Nonsuicidal Self-Injury.

  4. High Mood

    Time frame: Immediately following intervention or recruitment

    The main outcomes in this module are the lifetime prevalence of Manic Episode, Hypomanic, Bipolar I Disorder, Bipolar Sub Disorder, and Bipolar II Disorder

  5. Worry and Anxiety

    Time frame: Immediately following intervention or recruitment

    The main outcome in this module is the lifetime prevalence of Generalized Anxiety Disorder (GAD)

  6. Anger Attacks

    Time frame: Immediately following intervention or recruitment

    The main outcome in this module is the lifetime prevalence of Intermittent Explosive Disorder (IED)

  7. Panic Attacks

    Time frame: Immediately following intervention or recruitment

    The main outcomes in this module are the lifetime prevalence of Panic Attack and Panic Disorder.

  8. Obsessions and Compulsions

    Time frame: Immediately following intervention or recruitment

    The main outcome in this module is the lifetime prevalence of Obsessive-Compulsive Disorder (OCD)

  9. Stressful Experiences

    Time frame: Immediately following intervention or recruitment

    The main outcomes in this module are the lifetime prevalence of Posttraumatic Stress Disorder (PTSD), PCL-SC PTSD, and PCL-5 PTSD.

  10. Tobacco, Alcohol, and Drugs

    Time frame: Immediately following intervention or recruitment

    The main outcomes in this module are the lifetime prevalence of Alcohol Use Disorder (AUD) and Substance Use Disorder (SUD)

Study contacts

Contact information is provided by the study sponsor or research team.

Rusi Long, MHS

CONTACT

[email protected]

852+39102308

Yoona Kim, PhD

CONTACT

[email protected]

852+39179109

Sponsors and collaborators

Lead sponsor

The University of Hong Kong

Other

Registry information

Official study title

Use of Life History Calendars to Enhance Measurement of Lifetime Experience With Mental Disorders in Hong Kong.

Important dates

Study start
2025
Primary completion
2026
Study completion
2027
First posted
Feb 3, 2025
Registry last updated
Mar 10, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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