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NCT Number: NCT07600463

UVC in Prevention of Surgical Wound Infection

The LF-PODD study investigates the use of UVC (270nm) light in the prevention of surgical wound infections. Three devices are used in the study, two of which are actively producing UVC light (265 and 275 nm) and one device does not produce UVC light at all. The devices are outwardly completely identical and the devices are drawn for the research participants. Volunteers for neurosurgical procedures are selected for the study. Everyone participating in the study will be informed about the research and written consent will be requested. In the study, UVC light is focused on the surgical area at the beginning of the neurosurgical operation, during the operation, the device automatically dispenses UVC light into the air of the surgical area every 20 minutes, and at the end of the surgical procedure, the device delivers a single dose of UVC light to the surgical wound after closing the surgical wound. Study participants are monitored according to the standard treatment protocol and, in particular, the inflammation of the surgical wound is monitored. The results of the study are recorded and analysed using statistical methods.

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Key information

Conditions

Hydrocephalus Brain Diseases Central Nervous System Diseases Nervous System Diseases

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

About this study

The following are recruited for the study:

75 patients undergoing elective CSF shunt surgeries

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • 75 patients with idiopathic normal pressure hydrocephalus (iNPH) arriving for CSF shunt procedure
  • written informed consent

Exclusion criteria

  • immunosupressive medication
  • pregnancy
  • medication sensitizing for light exposure (e.g. doxycycline)

Treatment and study plan

UVC Irradiation

Device

UVC irradiation of surgical area

Primary outcomes

  1. The antimicrobial effects of UVC light in the edges of the surgical wound and nucleic acid detections

    Time frame: *immediately after surgery

    The ability of UVC light to reduce the incidence of LHI pathogens in surgical wounds: The antimicrobial effects of UVC light are investigated from smear samples taken from the edges of the surgical wound and nucleic acid detections, from which live and dead microbes can be determined.

Secondary outcomes

  1. Safety of UVC radiation

    Time frame: immediately after surgery

    Potential harm and benefits to surgical wound tissues: The potentially dangerous effects of healthy tissue at the cellular level are investigated from skin and subcutaneous tissue samples from the wound edge 2 mm x 1 cm.

Study contacts

Contact information is provided by the study sponsor or research team.

Paula Walle, MD PhD

CONTACT

[email protected]

+358447176321

Ville Leinonen, Professor

CONTACT

[email protected]

+358447172303 ext. +358447172303

Sponsors and collaborators

Lead sponsor

Ville Leinonen

Other

Collaborators

  • Led Future Oy

Registry information

Acronym: UVCJAS

Important dates

Study start
2026
Primary completion
2028
Study completion
2029
First posted
May 20, 2026
Registry last updated
May 20, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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