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Completed

NCT Number: NCT06390202

Uterine Artery Diastolic Notching & Apelin-13 and 36

This study was conducted to investigate the relationship between diastolic notching on uterine artery Doppler and serum apelin-13 and 36 concentrations between 11 and 14 weeks of gestation.

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Key information

Conditions

Diagnosis Disease Pathologic Processes Pathological Conditions, Signs and Symptoms

Age range

18 year–39 year

Sex eligibility

Female

Study type

Observational

Primary location

Ümraniye Training and Research Hospital

Istanbul, Ümraniye, 34764, Turkey (Türkiye)

About this study

Apelin-13 and apelin-36, which provide vasodilatation through a nitric oxide-dependent mechanism, also play a role in trophoblasts' survival, proliferation, and migration.

Based on this, we aimed to investigate serum apelin-13 and apelin-36 concentrations in pregnant women with and without diastolic notch on uterine artery Doppler between the 11th and 14th weeks of pregnancy.

We hypothesized that apelin-13 and apelin-36 might be associated with the formation of diastolic notch in uterine artery Doppler and serum apelin-13 and apelin-36 concentrations would be lower in the group with a notch in the uterine artery Doppler than in the group without a notch.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Nonsmokers,
  • Singleton pregnancies between 11 and 14 weeks of gestation
  • Pregnant women who did not conceive with assisted reproductive methods

Exclusion criteria

  • Smokers
  • Pregnant women who conceived with assisted reproductive techniques
  • Pregnant women with multiple pregnancies
  • Pregnant women who started with multiples and continued with singletons
  • Pregnant women with any pregestational disease, thrombophilia
  • Pregnant women with any congenital uterine anomaly
  • Pregnant women with a history of recurrent pregnancy loss
  • Pregnant women using aspirin or heparin

Treatment and study plan

No intervention

Other

there is no intervention in this study

Primary outcomes

  1. Relationship between diastolic notching on uterine artery Doppler and serum apelin-13 and apelin-36 concentrations.

    Time frame: through study completion, an average of 1 year

    Relationship between diastolic notching on uterine artery Doppler and serum apelin-13 and apelin-36 concentrations.

  2. Relationship between high pulsatility index on uterine artery Doppler and serum apelin-13 and apelin-36 concentrations.

    Time frame: through study completion, an average of 1 year

    Relationship between high pulsatility index on uterine artery Doppler and serum apelin-13 and apelin-36 concentrations.

Sponsors and collaborators

Lead sponsor

Umraniye Education and Research Hospital

Other Gov

Registry information

Official study title

Investigation of the Relationship Between Uterine Artery Doppler Diastolic Notching and Serum Apelin-13 and Apelin-36 Concentrations Between the 11th and 14th Weeks of Pregnancy

Important dates

Study start
2023
Primary completion
2023
Study completion
2024
First posted
Apr 30, 2024
Registry last updated
Apr 30, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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