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Completed

NCT Number: NCT07023705

MLPR As A Diagnostic Marker For Acute Pulmonary Embolism

A retrospective study to assess the utility of hematological marker (monocyte to large platelet ratio) to diagnose patients with pulmonary embolism

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Key information

Conditions

Pulmonary Embolism (Diagnosis) Cardiovascular Diseases Diagnosis Disease Embolism Embolism and Thrombosis Lung Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Pulmonary Embolism Respiratory Tract Diseases Vascular Diseases

Sex eligibility

All sexes

Study type

Observational

Primary location

Ain Shams University

Cairo, Egypt

About this study

The investigators conducted a retrospective review of emergency department records of patients who presented with signs and symptoms suggestive of pulmonary embolism (PE) and underwent CT pulmonary angiography (CTPA) for diagnosis. Hematological laboratory findings obtained prior to any treatment were collected and compared between two groups based on CTPA results: those with confirmed PE (CT positive) and those without PE (CT negative).

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Only patients with the results of full blood count and white blood cell differentiation, measured before the treatment of suspected PE.
  • Patients underwent CT pulmonary angiography to confirm or exclude pulmonary embolism diagnosis.

Exclusion criteria

  • Patient with history of any myeloproliferative disorder, myelofibrosis, Glanzmann thrombasthenia, May-Hegglin anomaly, Bernard-Soulier syndrome, suspicion of disseminated intravascular coagulation.
  • Patient receiving any anticoagulant drug at a therapeutic dose.
  • Patient with blood transfusion in the last 2 months.
  • Patients with acute coronary syndrome, pulmonary edema.
  • Patient on immunosuppressive drugs , Oral contraceptive pills .
  • Patients with severe renal or hepatic disease.
  • Patients with Stroke.
  • Patients with malignancy.

Treatment and study plan

Monocyte to Large Platelet Ratio (MLPR)

Diagnostic Test

Admission laboratory values were used to calculate the Monocyte-to-Large Platelet Ratio (MLPR) by dividing the absolute monocyte count by the large platelet count. These values were obtained from blood samples collected before any treatment was administered.

Primary outcomes

  1. Monocyte-to-Large Platelet Ratio (MLPR)

    Time frame: At emergency department admission (baseline lab measurement) before any treatment.

    A ratio between monocyte absolute count and the large platelets count (MLPR) values compared between groups using Mann-Whitney U test; diagnostic accuracy evaluated by area under the curve (AUC) , sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV).

Secondary outcomes

  1. Mean platelet volume (MPV)

    Time frame: At emergency department admission (baseline lab measurement) before any treatment.

    MPV values compared between groups using Mann-Whitney U test; diagnostic accuracy evaluated by AUC, sensitivity, specificity, PPV, and NPV.

  2. Neutrophil to Lymphocyte Ratio (NLR)

    Time frame: At emergency department admission (baseline lab measurement) before any treatment.

    The ratio between absolute neutrophil and absolute lymphocytes count (NLR) values compared between groups using Mann-Whitney U test; diagnostic accuracy evaluated by AUC, sensitivity, specificity, PPV, and NPV.

  3. D-Dimer Levels

    Time frame: At emergency department admission (baseline lab measurement) before any treatment.

    D-Dimer concentration values compared between groups using Mann-Whitney U test; diagnostic accuracy evaluated by AUC, sensitivity, specificity, PPV, and NPV.

  4. Platelet Distribution Width (PDW)

    Time frame: At emergency department admission (baseline lab measurement) before any treatment.

    PDW values compared between groups using Mann-Whitney U test; diagnostic accuracy evaluated by AUC, sensitivity, specificity, PPV, and NPV.

  5. Platelet To Lymphocyte Ratio (PLR)

    Time frame: At emergency department admission (baseline lab measurement) before any treatment.

    The ratio between total platelets count and absolute lymphocytes count (PLR) values compared between groups using Mann-Whitney U test; diagnostic accuracy evaluated by AUC, sensitivity, specificity, PPV, and NPV.

Sponsors and collaborators

Lead sponsor

Ain Shams University

Other

Registry information

Official study title

Monocyte To Large Platelet Ratio As A Diagnostic Marker For Acute Pulmonary Embolism

Important dates

Study start
2024
Primary completion
2024
Study completion
2025
First posted
Jun 17, 2025
Registry last updated
May 29, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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