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Completed

NCT Number: NCT06994832

Using Visual Arrays to Support Understanding of Genetic Risk

The goal of this study is to understand how people understand risk from genetic testing. The investigators want to understand what visual aid best helps people accurately assess risk. The investigators also want to understand how people relate risk to their health. The main questions the study aims to answer are:

1. Which visual aid most accurately show genetic risk? 2. How do people perceive risk related to genetic test results? 3. What factors are associated with people discussing their results with family?

Participants will:

1. receive of of two visual aids showing risk 2. state their estimation of risk 3. answer questions about how they feel about risk and sharing information with family

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Key information

Conditions

Decision Aid Colonic Diseases Colonic Neoplasms Colorectal Neoplasms Colorectal Neoplasms, Hereditary Nonpolyposis Congenital, Hereditary, and Neonatal Diseases and Abnormalities DNA Repair-Deficiency Disorders Digestive System Diseases Digestive System Neoplasms Gastrointestinal Diseases Gastrointestinal Neoplasms Genetic Diseases, Inborn Intestinal Diseases Intestinal Neoplasms Metabolic Diseases Neoplasms Neoplasms by Site Neoplastic Syndromes, Hereditary Nutritional and Metabolic Diseases Rectal Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Boston College

Boston, Massachusetts, 02467, United States

About this study

This study aims to determine what visual aid helps people most accurately interpret risk from genetic test results. The study also examines how people perceive risk using the Tripartite Risk Model. Last, the study examines factors that are associated with intention to share genetic test results with family members.

Participants will provide brief sociodemographic information, complete brief health literacy and numeracy assessments, and questions about how they perceive risk. Participants will be informed of a genetic testing scenario and will receive one of two visual aids. After reviewing the visual aid, participants will state the risk shown in the visual aid and will answer questions about their perceived risk and sharing results with family members (blood relatives).

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • ability to read and understand English
  • opt-in consent

Exclusion criteria

  • incorrect responses to validation questions

Treatment and study plan

Visual Array

Behavioral

Single side-by-side visual array

Narrative Visual Array

Behavioral

Evolving narrative with sequential visual arrays

Primary outcomes

  1. Risk Accuracy

    Time frame: immediately after the intervention

    closest approximation to risk percentage depicted in the visual array

Secondary outcomes

  1. Risk Perceptions

    Time frame: baseline

    Perceptions of deliberative, affective, and experiential risk using 7-point Likert-type scales

  2. Communication Intent

    Time frame: immediately after the intervention

    Intent to communicate risk to blood relatives using 7-point Likert-type scale

Sponsors and collaborators

Lead sponsor

Stephanie B. Seminara, MD

Other

Collaborators

  • Boston College
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

Registry information

Official study title

Examining Genetic Literacy and Numeracy in the General Population

Important dates

Study start
2025
Primary completion
2025
Study completion
2025
First posted
May 29, 2025
Registry last updated
Feb 18, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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