Use of Bivalirudin for Anticoagulation in Patients With Extracorporeal Membrane Oxygenation

Patients with ECMO who needed systemic anticoagulation were randomly divided into bivalirudin group and unfractionated heparin group;the efficacy of bivalirudin in ECMO anticoagulation was evaluated by comparing the percentage of time within the target anticoagulation level and the incidence of thrombotic complications between the two groups during ECMO; and the safety of bivalirudin in ECMO anticoagulation was evaluated by comparing bleeding complications, blood product infusion and the incidence of acute renal failure between the two groups.

Inclusion criteria

• Age ≥ 18 years old
• Accept VA-ECMO or VV-ECMO
• the ECMO team believes that systemic anticoagulation is necessary and that APTT should be maintained at 40-60s.
• sign the informed consent form

Exclusion criteria

• previous history of allergy to heparin or bivalirudin
• previous diagnosis of heparin-induced thrombocytopenia.
• the pre-random ECMO assistance time is more than 48 hours.
• pregnant female
• have participated in this study before.
• the researchers believe that there are other factors that are not suitable to participate in this study.