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Completed

NCT Number: NCT01694316

Use of a Novel Neuroplasticity-based Neurobehavioral Intervention for PTSD

The present study will explore the effectiveness of a computer based neurobehavioral intervention in alleviating symptoms and improving emotion regulation in individuals with PTSD. It will increase understanding of psychopathology at a neural-circuit level and aid development of new non-pharmacological treatment for PTSD. The study is managed by the Etkin Lab at Stanford University in California, but participants from the entire US are welcome to participate as the study is delivered online.

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Key information

Conditions

Anxiety Anxiety Disorders Behavior Behavioral Symptoms Depression Mental Disorders

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Stanford University, Department of Psychiatry and Behavioral Sciences

Stanford, California, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • current PTSD
  • internet access

Exclusion criteria

  • lifetime psychotic disorder,
  • past-year substance dependence

Treatment and study plan

Computerized neurobehavioral intervention

Behavioral

Targeted, computerized interventions completed from the participants' own home on a computer.

Primary outcomes

  1. WebNeuro Computerized Cognitive and Affective Assessment Battery

    Time frame: Baseline and 3-month

    Age and gender-normed Z scores for the following measures:

    Sustained attention accuracy, Sustained attention lapses, Sustained attention false alarms, Working memory capacity, Visual scanning speed, Inhibition executive control, Processing speed, Maze completion executive control accuracy, Maze completion executive control speed, Immediate verbal memory, Delayed verbal memory, Inhibitory motor control accuracy, Inhibitory motor control lapses, Facial affect identification accuracy (happy, fearful, angry, sad, and disgusted), Facial affect identification speed (happy, angry, fearful, sad, or disgusted), Facial affect identity recognition accuracy (happy, angry, sad, fearful, or disgusted), Facial affect identity recognition speed (happy, sad, angry, fearful, or disgusted), Emotional conflict reaction time slowdown, Regulation of emotional conflict reaction time slowdown

Secondary outcomes

  1. Clinician-assessed PTSD symptoms

    Time frame: Baseline and 3-month

    Total and symptom sub scale scores from the Clinician-Administered PTSD Scale for DSM-IV (CAPS)

Sponsors and collaborators

Lead sponsor

Stanford University

Other

Registry information

Official study title

Use of a Novel Neuroplasticity-based Neurobehavioral Intervention for PTSD - A Nationwide, Online Study

Important dates

Study start
2012
Primary completion
2017
Study completion
2017
First posted
Sep 27, 2012
Registry last updated
Aug 16, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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