Universitätsklinikum Frankfurt, Medizinische Klinik I, Gastroenterologie/Hepatologie; Frankfurt, Germany
Frankfurt, Germany
NCT Number: NCT05735886
To show that a natural mitophagy activator (Urolithin A) given orally can modulate mitochondrial activity in immune cells in healthy adults and this results in better immune function
Looking for future studies?
Notify Me45 year–70 year
All sexes
Interventional
Not applicable
Frankfurt, Germany
Healthy volunteers accepted: Yes
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
Healthy Adults that do not suffer from an uncontrolled chronic medical condition that carries metabolic consequences (as assessed by the study physician)
Exclusion criteria
Subject has any concurrent medical, orthopedic, or psychiatric condition that, in the opinion of the Investigator, would compromise his/her ability to comply with the study requirements;
Single oral dose administration (4 softgels) to be orally administered daily according to the randomization for 28 days
Single oral dose administration (4 softgels) to be orally administered daily according to the randomization for 28 days
Time frame: 28 days
In particular, number of CD8+ T memory stem cells (identified by expression of CD8+CD45RA+CCR7+CD95+) and naïve-like T cells (CD8+CD45RA+CCR7+CD95-)
Time frame: 28 days
Mitochondrial function evaluated as OXPHOS activity via ELISA /Seahorse
Time frame: 28 days
Time frame: 28 days
Time frame: 28 days
Time frame: 28 days
Time frame: 28 days
Time frame: 28 days
Time frame: 28 days
Time frame: 28 days
Amazentis SA
Industry
Impact of Urolithin A Supplementation on Mitochondrial Health of Immune Cells (MitoImmune): a Randomized Trial
OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.
View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.
Published trials that share one or more normalized conditions with this study.
NCT05610059
Aging, Behavior
Tucson, Arizona, United States
View Trial DetailsNCT05017129
Aging
Golden, Colorado, United States
View Trial DetailsNCT03814304
Accidental Falls, Aging
Roslindale, Massachusetts, United States
View Trial DetailsNCT05866393
Aging, Behavior
Cleveland, Ohio, United States
View Trial Details