Uric Acid Levels and Migraine in Childr… | Clinical Trial

Key information

Conditions

Migraine in Children Brain Diseases Central Nervous System Diseases Headache Disorders Headache Disorders, Primary Migraine Disorders Nervous System Diseases

Age range

6 year–18 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Mersin University

Mersin, 33000, Turkey (Türkiye)

About this study

Migraine is recognized as one of the most prevalent neurological disorders. The exact pathophysiological mechanisms underlying migraine have not yet been fully elucidated. The present study aims to compare serum uric acid levels between pediatric patients with migraine and a control group. Additionally, this study seeks to explore the potential relationship between migraine attack frequency and gender differences in pediatric patients Patients diagnosed with migraine were included as the study group, while the control group consisted of patients who presented to the pediatric neurology clinic during the same period for neuromotor development follow-up examinations.

Migraine patients are influenced by multiple factors, including dietary habits, levels of physical activity, and various psychosocial determinants.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients diagnosed with migraine

Exclusion criteria

Cerebral palsy Non-migraine headache Epilepsy Multiple congenital anomalies Congenital metabolic diseases Control group

Inclusion criteria

Healthy children Exclusion Criteria Neuromotor developmental delay Multiple congenital anomalies Non-migraine headache Epilepsy

Treatment and study plan

Primary outcomes

Evaluation of Uric Acid Levels in Pediatric Patients with Migraine

Time frame: 01.08.2019 and 01.03.2024

Migraine represents a significant neurological condition affecting individuals across all age groups, with a reported prevalence of 7.7% among children and adolescents. According to the widely accepted neurogenic inflammation hypothesis, sterile inflammation occurs in the dura mater surrounding the brain as a result of neuropeptide release from perivascular trigeminal nerve endings, leading to sensitization of sensory neurons .Uric acid is known to function as a potent endogenous antioxidant and free radical scavenger within the human body. It has been suggested that uric acid exerts dual effects on the central nervous system, demonstrating both neuroprotective and neurotoxic properties depending on its concentration. Although uric acid may enhance antioxidant and anti-inflammatory responses at physiological concentrations, it has been suggested that excessively elevated serum uric acid levels may contribute to increased oxidative stress and subsequent neuronal damage. The primary ou

Sponsors and collaborators

Lead sponsor

Aysen Orman

Other

Registry information

Official study title

Evaluation of Uric Acid Levels in Pediatric Patients With Migraine

Important dates

Study start: 2019
Primary completion: 2025
Study completion: 2025
First posted: May 11, 2025
Registry last updated: May 11, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed