Understanding How Anaesthesia Affects ECT Outcomes

This study will examine how anaesthetic technique affects ECT outcomes. Specifically, the investigators will examine how: 1) the time interval between anaesthetic and ECT stimulus, and 2) the ventilation rate before ECT stimulus, impacts on the quality of the EEG (this is a recording of brain activity during ECT and is used to judge the quality of a seizure and to guide individual patient dosing).

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Key information

Conditions

Depression Behavior Behavioral Symptoms

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 3

Primary location

Wesley Hospital Kogarah

Sydney, New South Wales, 2217, Australia

About this study

This study aims to examine how the time interval between administration of anaesthetic agent and ECT stimulus delivery impacts upon measures of EEG quality (seizure quality).

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients treated with a course of ECT

Exclusion criteria

Use of non-standard anaesthetic agents in ECT (e.g. ketamine)

Treatment and study plan

Electroconvulsive Therapy (ECT) time interval + Anaesthetic (Thiopentone)

Other

The intervention in this study is the time interval between anaesthetic administration and ECT stimulus

Primary outcomes

EEG Seizure Quality Rating using the EEG Seizure Quality Rating Sheet utilised by MacPherson et al

Time frame: Outcome measures will be collected immediately after each ECT treatment from the first treatment until the end of the ECT course, an estimated total of four to six weeks for most participants

EEG quality will be rated manually for each ECT treatment undertaken by a participant until the conclusion of their ECT course. This rating will be done using the EEG Seizure Quality Rating Sheet utilised by MacPherson et al - low dose lignocaine added to propofol does not attenuate the response to electroconvulsive therapy; Journal of Affective Disorders, 2010; 126: 330-333

Sponsors and collaborators

Lead sponsor

The University of New South Wales

Other

Collaborators

Wesley Mission

Registry information

Important dates

Study start: 2017
Primary completion: 2019
Study completion: 2019
First posted: Apr 7, 2017
Registry last updated: Mar 30, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed