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Completed

NCT Number: NCT04888065

Understand the Association Between Peritoneal Dialysis Status and Gene Polymorphisms of VEGF and KDR

Peritoneal dialysis (PD) is an effective and successful way of renal replacement therapy. The initial transport status is related to distribution of blood vessels and micro inflammation state in peritoneum before PD. Vascular endothelial growth factor(VEGF) and its receptor, kinase insert domain containing receptor(KDR) may play important roles on initial transport status.

This study include 200 PD patients from Renji Hospital in Shanghai, China. According to the 4h D/P Cr within three months of starting PD therapy, we analyzed the association between the polymorphisms of VEGF and KDR and initial peritoneal transport property.

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Key information

Conditions

Peritoneal Dialysis

Sex eligibility

All sexes

Study type

Observational

Primary location

Renji Hospital

Shanghai, Shanghai Municipality, 310115, China

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients are Han Chinese;
  • Patients prepare for dialysis in our center, and start PD within 3 months after abdominal catheterization;
  • Patients successfully complete the first peritoneal equilibration test(PET);
  • Follow up regularly in our PD center.

Exclusion criteria

  • Patients from hemodialysis to peritoneal dialysis;
  • Patients who need peritoneal dialysis due to transplant-renal loss;

Treatment and study plan

Primary outcomes

  1. The relationship between VEGF and KDR Gene polymorphisms and initial transport status in peritoneal dialysis

    Time frame: For each patient, the outcome would be cross sectional measured at the time the patient does first/initial Peritoneal Equilibration Test. The data collection time period of the study is within 3 months.

    According to the 4h dialysate over plasma ratio for creatinine （D/P Cr） within three months of starting PD therapy, patients were divided into high transport(H) or high average transport(HA) (H/HA) group and low transport(L) or low average transport(LA) (L/LA) group. Gene polymorphisms of selected VEGF and KDR SNPs were analyzed using extracted blood DNA from these patients. We aimed to investigate the relationship between VEGF and KDR gene polymorphisms and initial peritoneal transport property.

Sponsors and collaborators

Lead sponsor

RenJi Hospital

Other

Registry information

Official study title

Gene Polymorphisms of VEGF and KDR Are Associated With Initial High Transport Status in Peritoneal Dialysis

Important dates

Study start
2018
Primary completion
2020
Study completion
2020
First posted
May 17, 2021
Registry last updated
May 17, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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