Skip to main content
OpenTrials
Completed

NCT Number: NCT07634211

Combined Aerobic and Resistance Exercise in Peritoneal Dialysis Patients

The goal of this randomized controlled trial was to learn whether a combined aerobic and resistance exercise program could improve physical function and muscle health in people receiving peritoneal dialysis. Researchers compared an exercise group with a control group to evaluate the effects of regular exercise.

The main questions the study aimed to answer were:

* Can regular exercise improve physical performance and muscle strength in people receiving peritoneal dialysis? * Can regular exercise improve body composition and blood markers related to muscle health?

Before the exercise program, participants completed a one-month training period to learn the exercises and practice them safely.

Participants in the exercise group:

* Performed combined aerobic and resistance exercises for 8 weeks * Completed assessments before and after the exercise program

Participants in the control group:

* Continued their usual care * Completed assessments before and after the study period

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Peritoneal Dialysis Behavior Motor Activity

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Mugla Sitki Kocman University Faculty of Medicine, Mugla Training and Research Hospital

Muğla, 48000, Turkey (Türkiye)

About this study

People receiving peritoneal dialysis often experience reduced physical function, muscle weakness, and changes in body composition. This randomized controlled trial evaluated the effects of a combined aerobic and resistance exercise program in adults receiving peritoneal dialysis.

Before the intervention, participants completed a one-month training and adaptation period to learn the exercises and ensure safe participation. Participants were then assigned to either an exercise group or a control group. The exercise group performed a structured combined aerobic and resistance exercise program for 8 weeks, while the control group continued usual care.

Researchers evaluated physical performance, muscle strength, body composition, and blood markers related to muscle health before and after the intervention period. The study aimed to determine whether regular exercise could improve physical function and muscle health in people receiving peritoneal dialysis.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adults aged 18 years or older
  • Receiving peritoneal dialysis for at least 6 months
  • Ability to sit and stand independently

Exclusion criteria

  • Myocardial infarction within the previous 6 months
  • History of cardiac surgery
  • Uncontrolled hypertension
  • Pericardial or pleural effusion
  • Aortic stenosis
  • Active lower extremity amputation, prosthesis, or fracture
  • History of osteoporotic fractures
  • Regular participation in sports or structured exercise
  • Advanced cognitive impairment

Treatment and study plan

Combined Aerobic and Resistance Exercise

Behavioral

Participants performed a structured combined aerobic and resistance exercise program for 8 weeks. Before the intervention period, participants completed a one-month training and adaptation phase to learn the exercises and ensure safe participation. The exercise program aimed to improve physical performance, muscle strength, and muscle health in people receiving peritoneal dialysis.

Primary outcomes

  1. Physical Performance

    Time frame: Baseline and after 8 weeks of intervention

    Changes in physical performance assessed using the 6-minute walk test after 8 weeks of combined aerobic and resistance exercise.

  2. Changes in right handgrip strength

    Time frame: Baseline and after 8 weeks of intervention

    Changes in right handgrip strength measured in kilograms after 8 weeks of combined aerobic and resistance exercise.

  3. Changes in left handgrip strength

    Time frame: Baseline and after 8 weeks of intervention

    Changes in left handgrip strength measured in kilograms after 8 weeks of combined aerobic and resistance exercise.

  4. Changes in leg strength

    Time frame: Baseline and after 8 weeks of intervention

    Changes in lower extremity muscle strength measured using a leg and back dynamometer after 8 weeks of combined aerobic and resistance exercise.

Secondary outcomes

  1. Changes in flexibility

    Time frame: Baseline and after 8 weeks of intervention

    Changes in flexibility assessed using the Modified Back-Saver Sit-and-Reach Test after 8 weeks of combined aerobic and resistance exercise.

  2. Changes in Fat Tissue Index (FTI)

    Time frame: Baseline and after 8 weeks of intervention

    Changes in Fat Tissue Index measured by by bioimpedance spectroscopy after 8 weeks of combined aerobic and resistance exercise.

  3. Changes in Lean Tissue Index (LTI)

    Time frame: Baseline and after 8 weeks of intervention

    Changes in Lean Tissue Index measured by by bioimpedance spectroscopy after 8 weeks of combined aerobic and resistance exercise.

  4. Changes in serum IGF-1 levels

    Time frame: Baseline and after 8 weeks of intervention

    Changes in serum insulin-like growth factor-1 (IGF-1) levels after 8 weeks of combined aerobic and resistance exercise.

  5. Changes in serum ACTH levels

    Time frame: Baseline and after 8 weeks of intervention

    Changes in serum adrenocorticotropic hormone (ACTH) levels after 8 weeks of combined aerobic and resistance exercise.

  6. Changes in serum myostatin levels

    Time frame: Baseline and after 8 weeks of intervention

    Changes in serum myostatin levels after 8 weeks of combined aerobic and resistance exercise.

  7. Changes in serum irisin levels

    Time frame: Baseline and after 8 weeks of intervention

    Changes in serum irisin levels after 8 weeks of combined aerobic and resistance exercise.

Other outcomes

  1. Changes in biceps skinfold thickness

    Time frame: Baseline and after 8 weeks of intervention

    Changes in biceps skinfold thickness measured using skinfold caliper assessment after 8 weeks of combined aerobic and resistance exercise.

  2. Changes in triceps skinfold thickness

    Time frame: Baseline and after 8 weeks of intervention

    Changes in triceps skinfold thickness measured using skinfold caliper assessment after 8 weeks of combined aerobic and resistance exercise.

  3. Changes in abdominal skinfold thickness

    Time frame: Baseline and after 8 weeks of intervention

    Changes in abdominal skinfold thickness measured using skinfold caliper assessment after 8 weeks of combined aerobic and resistance exercise.

Sponsors and collaborators

Lead sponsor

Dilek GİBYELİ GENEK

Other

Collaborators

  • Muğla Sıtkı Koçman University

Registry information

Official study title

Combined Aerobic and Resistance Exercise in Peritoneal Dialysis Patients: A Randomized Controlled Trial

Acronym: CAPER-PD

Important dates

Study start
2022
Primary completion
2022
Study completion
2022
First posted
Jun 8, 2026
Registry last updated
Jun 8, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.