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NCT Number: NCT06733740

Ultrasound-guided Thermal Ablation for Papillary Thyroid Carcinoma

To evaluate long-term outcomes of ultrasound-guided thermal ablation for the treatment of papillary thyroid carcinoma

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Key information

Conditions

Papillary Thyroid Cancer Adenocarcinoma Adenocarcinoma, Papillary Carcinoma Endocrine Gland Neoplasms Endocrine System Diseases Head and Neck Neoplasms Neoplasms Neoplasms by Histologic Type Neoplasms by Site Neoplasms, Glandular and Epithelial Thyroid Cancer, Papillary Thyroid Diseases Thyroid Neoplasms

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Chinese PLA General Hospital

Beijing, Beijing Municipality, 100853, China

Location status: Recruiting

Location contact

Lin Yan

CONTACT

About this study

To evaluate and predict long-term clinical outcomes of ultrasound-guided thermal ablation for the treatment of papillary thyroid carcinoma by a multicenter study

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • patients age between 18 and 80 year old, both sex
  • papillary thyroid carcinoma confirmed by core-needle biopsy or fine-needle aspiration
  • the largest diameter ≤2.0 cm
  • no clinical or imaging evidences of extrathyroidal extension, lymph node metastasis and distant metastasis on ultrasound, neck and chest CT
  • follow-up period ≥12 months

Exclusion criteria

  • patients with convincing evidence of aggressive papillary thyroid carcinoma or other type of thyroid cancer by biopsy
  • history of neck radiation
  • coagulation disorder, serious heart, respiratory, liver, or renal failure
  • dysfunction of the vocal cord on the opposite side

Treatment and study plan

ultrasound-guided thermal ablation

Procedure

ultrasound-guided thermal ablation to treat tumor

Primary outcomes

  1. rate of disease progression

    Time frame: through study completion, an average of 6 months

    cervical lymph node metastases, recurrent tumors and persistent tumors confirmed by pathology

Secondary outcomes

  1. Rate of complications

    Time frame: 1 week

    complications of ablation

  2. Rate of tumor disappearance

    Time frame: through study completion, an average of 6 months

    complete disappearance of ablated tumor on ultrasound and contrast-enhanced ultrasound

  3. Rate of volume reduction

    Time frame: through study completion, an average of 6 months

    volume reduction of tumor after ablation on ultrasound and contrast-enhanced ultrasound

  4. rate of change of thyroid function

    Time frame: through study completion, an average of 6 months

    thyroid function test, including free triiodothyronine, free thyroxine, thyroid stimulating hormone, thyroid peroxidase antibody and anti-thyroglobulin antibodies

  5. rate of delayed surgery

    Time frame: through study completion, an average of 1 year

    patients underwent surgery after ablation because of anxiety

Study contacts

Contact information is provided by the study sponsor or research team.

Lin Yan, MD

CONTACT

[email protected]

13811237313 ext 86

Sponsors and collaborators

Lead sponsor

Chinese PLA General Hospital

Other

Registry information

Official study title

The Clinical Outcomes of Ultrasound-guided Thermal Ablation for the Treatment of Papillary Thyroid Carcinoma: A Multicenter Study

Important dates

Study start
2024
Primary completion
2028
Study completion
2030
First posted
Dec 13, 2024
Registry last updated
Feb 14, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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