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NCT Number: NCT06316895

The Clinical Outcomes and Prediction of Thermal Ablation for Low-risk Papillary Thyroid Carcinoma

1. To evaluate the clinical outcomes of ultrasound-guided thermal ablation and thyroid surgery for the treatment of papillary thyroid carcinoma; 2. To develop and validate a artificial intelligence model to predict the outcomes of ultrasound-guided thermal ablation in the treatment of papillary thyroid carcinoma;

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Key information

Conditions

Papillary Thyroid Cancer Adenocarcinoma Adenocarcinoma, Papillary Carcinoma Endocrine Gland Neoplasms Endocrine System Diseases Head and Neck Neoplasms Neoplasms Neoplasms by Histologic Type Neoplasms by Site Neoplasms, Glandular and Epithelial Thyroid Cancer, Papillary Thyroid Diseases Thyroid Neoplasms

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Chinese PLA General Hospital

Beijing, China

Location status: Recruiting

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • patients age between 18 and 80 year old, both sex
  • papillary thyroid carcinoma confirmed by core-needle biopsy or fine-needle aspiration
  • the largest diameter ≤2.0 cm
  • no clinical or imaging evidences of extrathyroidal extension, lymph node metastasis and distant metastasis on ultrasound, nech and chest CT
  • follow-up period ≥12 months,

Exclusion criteria

  • patients with convincing evidence of aggressive papillary thyroid carcinoma or other type of thyroid cancer by biopsy
  • history of neck radiation
  • history of thyroid surgery
  • coagulation disorder
  • serious heart, respiratory, liver, or renal failure
  • dysfunction of the vocal cord on the opposite side

Treatment and study plan

Thyroid Surgery

Procedure

thyroid lobectomy

ultrasound-guided thermal ablation

Procedure

radiofrequency ablation; microwave ablation or laser ablation

Primary outcomes

  1. rate of disease progression

    Time frame: more than 5 year

    cervical lymph node metastases, recurrent tumors and persistent tumors

Secondary outcomes

  1. Rate of complications

    Time frame: 1week

    surgery or ablation complications

  2. Rate of tumor disappearance

    Time frame: 2 year

    complete disappearance of ablated tumor on ultrasound and contrast-enhanced ultrasound

Study contacts

Contact information is provided by the study sponsor or research team.

Lin Yan, MD

CONTACT

[email protected]

13811237313 ext. 86

Sponsors and collaborators

Lead sponsor

Chinese PLA General Hospital

Other

Registry information

Official study title

The Clinical Outcomes and Artificial Intelligence Prediction Model of Ultrasound-guided Thermal Ablation for the Treatment of Low-risk Papillary Thyroid Carcinoma

Important dates

Study start
2024
Primary completion
2027
Study completion
2029
First posted
Mar 19, 2024
Registry last updated
Mar 20, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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