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NCT Number: NCT07692659

Ultrasound-Guided Parasternal/Rectus Sheath Block vs Erector Spinae Plane Block for Pain Control in Cardiac Surgery

The researchers are working to improve recovery after heart surgery by reducing reliance on opioids. Newer regional anesthesia techniques can provide strong pain relief with fewer risks, but the choice of method depends on each patient's condition, medications, and surgical plan

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Key information

About this study

Optimal anesthesia in cardiac surgery requires careful management to avoid sympathetic stimulation, with analgesia being central to patient safety and recovery. Traditionally, high-dose opioids were used, but this approach delays extubation, conflicting with fast-track protocols that emphasize early extubation. Consequently, opioid-free analgesia has gained importance, employing regional techniques such as neuraxial, paravertebral, and fascial plane blocks.

Thoracic epidural analgesia (TEA) offers effective pain control and reduces perioperative cardiovascular and respiratory complications. However, its use in anticoagulated patients raises concern for epidural hematoma. Alternatives like paravertebral and fascial plane blocks provide comparable analgesia with lower risk. The erector spinae plane block (ESPB) reduces analgesic requirements, though deep blocks still pose bleeding risks.

Superficial plane blocks are therefore clinically valuable. The parasternal intercostal block-targeting anterior cutaneous branches of intercostal nerves-has emerged as a safe option for patients undergoing median sternotomy while on anticoagulant or antiplatelet therapy. Additionally, bilateral rectus sheath block can reduce chest tube insertion pain after cardiac surgery.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Both sexes,
  • ASA III-IV patients
  • body mass index between 20- 35 kg/m2
  • adult patients above 18 years old will be included in the study

Exclusion criteria

  • Patients with global hypokinesia
  • ejection fraction < 40%
  • low platelet count
  • coagulation impairment
  • deformity in the vertebral column
  • severe renal and hepatic impairment
  • any known allergy to the drugs used

Treatment and study plan

Parasternal/ Rectus sheath block

Procedure

the parasternal block will be performed parasternally at the level of fifth rib to the plane between the pectoralis major and the internal intercostal muscle. The rectus sheath block will be performed through injection in the plane posterior to the rectus abdominis muscle and anterior to the posterior rectus sheath

Erector Spinae Plane Block

Procedure

injection above the transverse process

Primary outcomes

  1. Numeric rating score

    Time frame: 24 hours

    postoperative pain scores using Numerical Rating Scale (NRS) with 0 meaning no pain and 10 meaning the worst pain level

Secondary outcomes

  1. postoperative opioid consumption

    Time frame: 24 hours

    opioid consumption in the first 24 hours postoperatively

  2. extubation time

    Time frame: immediate postoperative

    time to extubate

  3. first time to request analgesia

    Time frame: 24 hours

    first time to request opioid analgesia

  4. peri-operative hemodynamics

    Time frame: intraoperative and 24 hours

    incidence of hypotension, hypertension, tachycardia and bradycardia

Study contacts

Contact information is provided by the study sponsor or research team.

Mostafa A Ibrahim, MD

CONTACT

[email protected]

+966541227090

Walaa Y Elsabeeny, MD

CONTACT

[email protected]

01007798466

Sponsors and collaborators

Lead sponsor

National Cancer Institute, Egypt

Other

Collaborators

  • Saudi German Hospital - Madinah

Registry information

Official study title

Comparison of Ultrasound Guided Bilateral Parasternal Block With Bilateral Rectus Sheath Block Versus Ultrasound Guided Bilateral Erector Spinae Plane Block in Controlling Intra and Post-operative Pain After Cardiac Surgeries

Important dates

Study start
2026
Primary completion
2027
Study completion
2027
First posted
Jul 9, 2026
Registry last updated
Jul 13, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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