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NCT Number: NCT07736989

Ultrasound-Guided Bilateral Transversalis Fascia Plane Block With vs Without Dexamethasone for Cesarean Delivery

Cesarean delivery is one of the most frequently performed surgical procedures worldwide, and effective postoperative pain management is essential to facilitate early mobilization, maternal-infant bonding, breastfeeding, and overall recovery. Ultrasound-guided transversalis fascia plane block (TFPB) has become an increasingly utilized component of multimodal analgesia following cesarean delivery because it provides effective somatic analgesia of the lower anterior abdominal wall. Adjuvants such as dexamethasone are frequently added to local anesthetics with the aim of prolonging block duration and improving postoperative analgesia; however, evidence regarding the clinical benefits of dexamethasone as an adjunct in TFPB remains limited.

At our institution, bilateral ultrasound-guided TFPB is routinely performed for postoperative analgesia in patients undergoing cesarean delivery under spinal anesthesia, provided there is no contraindication and informed consent has been obtained. According to the treating anesthesiologist's routine clinical preference, dexamethasone may be added to the local anesthetic solution in some patients, whereas others receive local anesthetic alone. This retrospective cohort study will review the medical records and postoperative follow-up forms of patients who underwent cesarean delivery between November 1, 2025, and June 30, 2026. Postoperative analgesic outcomes, including opioid consumption, pain scores, time to first analgesic request, postoperative nausea and vomiting, recovery quality, and block-related adverse events, will be compared between patients receiving bilateral TFPB with dexamethasone and those receiving bilateral TFPB without dexamethasone. The findings are expected to provide real-world evidence regarding the potential contribution of dexamethasone to the analgesic efficacy of bilateral TFPB following cesarean delivery.

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Key information

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Female patients aged 18-50 years.
  • Elective cesarean delivery performed under spinal anesthesia.
  • Bilateral ultrasound-guided transversalis fascia plane block performed for postoperative analgesia.
  • Availability of complete perioperative and postoperative follow-up records.

Exclusion criteria

  • Emergency cesarean delivery.
  • General anesthesia or combined spinal-epidural anesthesia.
  • Contraindication to transversalis fascia plane block.
  • Chronic opioid use.
  • Allergy to bupivacaine or dexamethasone.
  • Missing or incomplete postoperative follow-up data.

Treatment and study plan

Primary outcomes

  1. Cumulative opioid consumption during the first 24 postoperative hours

    Time frame: First 24 hours after surgery

    Total opioid consumption delivered through the patient-controlled analgesia device during the first 24 hours after surgery, expressed in mg. Patients were instructed to use the PCA device when the Numeric Rating Scale pain score was 4 or higher.

Secondary outcomes

  1. Postoperative pain intensity

    Time frame: 1, 3, 6, 9, 12, 18, and 24 hours after surgery

    Pain intensity assessed using the Numeric Rating Scale (NRS, 0-10).

  2. Time to first analgesic request

    Time frame: Within the first 24 postoperative hours

    Time from completion of surgery to the first patient-controlled analgesia (PCA) demand for postoperative analgesia.

  3. Quality of postoperative recovery

    Time frame: 24 hours after surgery

    Quality of recovery assessed using the ObsQoR-10 questionnaire.

Study contacts

Contact information is provided by the study sponsor or research team.

Selma Kahyaoglu

CONTACT

[email protected]

+905053705332

selma basyigit

CONTACT

[email protected]

+905053705332

Sponsors and collaborators

Lead sponsor

Bahçeşehir University

Other

Registry information

Official study title

Postoperative Analgesic Outcomes After Bilateral Ultrasound-Guided Transversalis Fascia Plane Block With or Without Dexamethasone in Cesarean Delivery: A Retrospective Cohort Study

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Jul 30, 2026
Registry last updated
Jul 30, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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