NCT Number: NCT07324863
This study aims to evaluate the efficacy of ultrasound-guided external oblique and rectus abdominis plane block on the neuroendocrine stress response and postoperative analgesia in adults undergoing umbilical hernia repair.
Interested in participating?
Request Info21 year–65 year
All sexes
Interventional
Not applicable
Tanta, 31527, Egypt
Location status: Recruiting
Alaa M Abo Hagar, MD
SUB_INVESTIGATOR
Gehan M Morsy, MD
SUB_INVESTIGATOR
Lobna M Khalil, MD
SUB_INVESTIGATOR
Mayada H Sokeer, Master
CONTACT
Nashwa E Hamoda, MD
SUB_INVESTIGATOR
Umbilical hernias of the abdomen are defined as a non-inguinal, non-hiatal defect in the fascia of the abdominal wall. Surgical stress response refers to the physiologic response to surgery and the hormonal and metabolic changes that follow it.
Fascial plane blocks are gaining attention for perioperative analgesia due to their efficacy and safety profiles. The external oblique and rectus abdominis plane (EXORA) block is an emerging technique that provides a sensory block to the anterolateral abdominal wall, potentially filling gaps left by other commonly used blocks, such as the quadratus lumborum (QLB) or erector spinae plane (ESP) blocks.
Healthy volunteers accepted: No
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
Exclusion criteria
Patients will receive general anesthesia only.
Patients will receive general anesthesia and an external oblique and rectus abdominis plane (EXORA) block with 0.25% bupivacaine.
Time frame: 24 hours postoperatively
Neuroendocrine stress response will be measured by blood glucose level in adults undergoing umbilical hernia repair.
Time frame: 24 hours postoperatively
Serum cortisol level will be measured.
Time frame: 24 hours postoperatively
Time of first rescue analgesia will be recorded from the end of surgery till first dose of morphine administration.
Time frame: Intraoperatively
Rescue dose of intraoperative fentanyl given will be recorded.
Time frame: 24 hours postoperatively
Intravenous morphine (rescue analgesic) at a dosage of 3 mg will be administered when the Numerical Rating Scale (NRS) score will be ≥ 4. The total morphine consumption over a 24-hours period will be recorded for these individuals.
Time frame: 24 hours postoperatively
Each patient will be instructed in postoperative pain assessment using the Numerical Rating Scale (NRS), ranging from 0 to 10 (0 = "no pain," 10 = "the worst pain imaginable"). NRS will be assessed at post-anesthesia care unit (PACU),1,2,4,6,12,24 hours postoperative
Contact information is provided by the study sponsor or research team.
Tanta University
Other
The Effect of Ultrasound Guided External Oblique and Rectus Abdominis Plane Block (EXORA) on Neuroendocrine Stress Response in Adults Undergoing Umbilical Hernia Surgery: A Prospective Randomized Controlled Trial
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