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NCT Number: NCT07343557

Ultrasound-Based Airway Assessment for Predicting Difficult Intubation in Adult Female Patients

This prospective observational study aims to evaluate the ability of selected ultrasonographic airway measurements to predict difficult intubation in adult female patients undergoing elective surgery. Pre-induction airway ultrasonography will be performed to measure tongue thickness and anterior neck soft tissue-related parameters. These measurements will be compared with laryngoscopic findings during direct laryngoscopy. The results of this study may help identify practical and reliable ultrasound-based markers for preoperative airway assessment and improve patient safety.

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Key information

Age range

18 year–65 year

Sex eligibility

Female

Study type

Observational

Primary location

Adana City Training and Research Hospital

Adana, 010650, Turkey (Türkiye)

About this study

This is a prospective, single-center observational study conducted in adult female patients scheduled for elective surgery under general anesthesia. The study was performed at the University of Health Sciences Adana City Training and Research Hospital after approval by the institutional ethics committee.

Before induction of anesthesia, standardized ultrasonographic airway assessments were performed by an experienced anesthesiologist. Measurements included tongue thickness, the distance from the skin to the anterior commissure of the vocal cords, the distance from the skin to the hyoid bone, and the distance from the skin to the epiglottis. All measurements were obtained under static pre-induction conditions using portable ultrasound equipment.

Following anesthesia induction, direct laryngoscopy was performed, and laryngoscopic view was graded according to the Cormack-Lehane classification. Difficult intubation was defined based on predefined laryngoscopic criteria. Ultrasonographic measurements were then analyzed for their diagnostic performance in predicting difficult intubation.

The primary objective of the study was to determine the most informative ultrasonographic parameter for predicting difficult intubation in this population. Secondary objectives included comparing the relative diagnostic value of different ultrasound measurements and evaluating their potential role in routine preoperative airway assessment.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Female patients aged 18-65 years
  • American Society of Anesthesiologists (ASA) physical status I-III physical status I-III
  • Scheduled for elective surgery under general anesthesia requiring tracheal intubation
  • Ability to provide informed consent

Exclusion criteria

  • Body mass index ≥30 kg/m²
  • Known history of difficult intubation
  • Anatomical airway abnormalities or head and neck pathology
  • Pregnancy
  • Emergency surgery

Treatment and study plan

Primary outcomes

  1. Incidence of Difficult Intubation

    Time frame: Perioperative

    Difficult intubation defined as Cormack-Lehane grade III or IV and/or the need for additional airway devices or techniques during tracheal intubation.

Secondary outcomes

  1. Ultrasonographic Measurement of Tongue Thickness

    Time frame: Preoperative assessment

    Preoperative ultrasonographic measurement of tongue thickness performed in the suprahyoid region.

  2. Ultrasonographic Measurement of Skin-to-Hyoid Bone Distance

    Time frame: Preoperative assessment

    Preoperative ultrasonographic measurement of the distance between the skin and the hyoid bone.

  3. Ultrasonographic Measurement of Skin-to-Epiglottis Distance

    Time frame: Preoperative assessment

    Preoperative ultrasonographic measurement of the distance between the skin and the epiglottis.

  4. Ultrasonographic Measurement of Distance from Skin to Anterior Commissure of the Vocal Cords

    Time frame: Preoperative assessment

    Preoperative ultrasonographic measurement of the distance from the skin to the anterior commissure of the vocal cords.

Sponsors and collaborators

Lead sponsor

Adana City Training and Research Hospital

Other

Registry information

Official study title

Diagnostic Performance of Ultrasonographic Airway Measurements for Predicting Difficult Intubation in Adult Female Patients: A Prospective Observational Study

Acronym: USG-AIRWAY

Important dates

Study start
2025
Primary completion
2025
Study completion
2025
First posted
Jan 15, 2026
Registry last updated
Jan 15, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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