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OpenTrials
Completed

NCT Number: NCT07383610

Ultrasound Predictors of Difficult Airway in Adults

Difficult airway management is a major cause of perioperative complications. Standard bedside airway assessment tests may have limited ability to predict difficult intubation and difficult mask ventilation. This prospective observational study aims to evaluate whether preoperative ultrasound measurements of airway structures (such as skin-to-epiglottis distance, tongue thickness, and pre-epiglottic space) can predict difficult intubation and difficult mask ventilation in adult patients undergoing surgery under general anesthesia.

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Key information

Age range

18 year–70 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Kütahya Health Sciences University

Kütahya, 3100, Turkey (Türkiye)

About this study

This prospective observational cohort study was conducted to evaluate the predictive value of preoperative ultrasonographic airway measurements for difficult intubation and difficult mask ventilation in adult patients undergoing elective surgery under general anesthesia. A total of 400 patients aged 18-70 years with ASA physical status I-III were included. Before induction of anesthesia, standard clinical airway assessment tests were recorded, and ultrasound measurements were performed to assess airway-related anatomical structures. Ultrasonographic parameters included skin-to-epiglottis distance, skin-to-thyroid cartilage distance, thyroid cartilage-to-epiglottis distance, pre-epiglottic space depth, tongue thickness, and hyomental distance measurements.

Intraoperatively, mask ventilation and intubation conditions were documented. Difficult intubation was defined as requiring two or more intubation attempts. Difficult mask ventilation was defined as the need for two-handed mask ventilation or inability to ventilate adequately using a face mask. The primary objective was to determine the association between ultrasonographic measurements and difficult intubation

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age 18-70 years

ASA physical status I-III

Elective surgery under general anesthesia requiring orotracheal intubation

Written informed consent

Exclusion criteria

  • Refusal to participate

Emergency surgery

Pregnancy

Known upper airway pathology or previous airway surgery

Restricted mouth opening (<3 cm)

Cervical spine instability or significant limitation of neck mobility

Morbid obesity (BMI ≥40 kg/m²)

Obstructive upper airway masses (e.g., head and neck tumors)

Prior neck radiotherapy

Clinically relevant neck masses

Major facial/mandibular trauma or craniofacial anomalies

Treatment and study plan

Primary outcomes

  1. Number of Participants with Difficult Intubation

    Time frame: During induction of anesthesia (intraoperative)

    Difficult intubation was defined as requiring two or more intubation attempts (≥2 attempts) during induction of general anesthesia.

  2. Number of Participants with Difficult Mask Ventilation

    Time frame: During induction of anesthesia (intraoperative)

    Difficult mask ventilation was defined as the need for two-handed mask ventilation or inability to ventilate adequately using a face mask

Sponsors and collaborators

Lead sponsor

Kutahya Health Sciences University

Other

Registry information

Official study title

Investigation of Ultrasonographic Predictors of Difficult Intubation and Difficult Mask Ventilation in Adult Patients

Important dates

Study start
2023
Primary completion
2024
Study completion
2024
First posted
Feb 3, 2026
Registry last updated
Feb 5, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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