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Completed

NCT Number: NCT07305909

Two- and Three-Dimensional Quantification of Facial Symmetry After Fat Grafting and Free Flap Reconstruction in Hemifacial Atrophy

Hemifacial atrophy causes one side of the face to become smaller, leading to facial asymmetry. Surgeons often restore facial volume using either autologous fat grafting or free-flap reconstruction. However, it is not fully clear how much facial symmetry improves after surgery when measured objectively using two-dimensional (2D) photographs and three-dimensional (3D) surface scans.

This is a single-center, retrospective observational study of patients with hemifacial atrophy treated between January 2020 and December 2023 at [Plastic Surgery Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College]. We will quantify facial symmetry before surgery and at the first follow-up visit occurring at or beyond 6 months after the initial surgery. Symmetry outcomes will be assessed using standardized 2D photographs for all included patients, and 3D surface scans for a subset of patients. Complications will also be assessed at the first ≥6-month follow-up visit. We will compare changes in symmetry between patients treated with fat grafting and those treated with free-flap reconstruction.

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Key information

Sex eligibility

All sexes

Study type

Observational

Primary location

Plastic Surgery Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College

Beijing, Beijing Municipality, 100144, China

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Diagnosis of hemifacial atrophy (Parry-Romberg syndrome).

Underwent initial soft-tissue augmentation with either autologous fat grafting or free-flap reconstruction at the study center between January 2020 and December 2023.

Availability of standardized preoperative assessment and postoperative assessment at the first follow-up visit occurring ≥6 months after surgery (2D photographs required).

Exclusion criteria

Follow-up <6 months after the initial surgery.

Missing key imaging/photographic data required for outcome assessment.

Any additional facial augmentation or revision procedure performed before the first ≥6-month follow-up visit.

Treatment and study plan

Primary outcomes

  1. Change in 2D Facial Symmetry Ratio

    Time frame: Baseline (preoperative) and first follow-up visit 6 months postoperatively

    Facial symmetry ratio calculated from standardized frontal 2D photographs using computerized photogrammetric analysis. The primary endpoint is the change from preoperative baseline to the first postoperative follow-up visit occurring at or beyond 6 months after the initial surgery.

Secondary outcomes

  1. Change in 3D Volumetric Discrepancy Between Hemifaces

    Time frame: Baseline (preoperative) and first follow-up visit 6 months postoperatively

    Three-dimensional (3D) volumetric discrepancy between the affected and unaffected hemiface measured from 3D surface scans in the subset of participants with available 3D data. Change from baseline to the first ≥6-month follow-up visit.

Sponsors and collaborators

Lead sponsor

Peking Union Medical College

Other

Collaborators

  • The Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College

Registry information

Official study title

Two- and Three-Dimensional Quantification of Facial Symmetry Following Fat Grafting Versus Free Flap Reconstruction in Hemifacial Atrophy: A Retrospective Observational Study

Important dates

Study start
2020
Primary completion
2023
Study completion
2023
First posted
Dec 26, 2025
Registry last updated
Dec 26, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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