Ultrasound-guided Combined Perineural and Intramuscular Dextrose Injection for Management of Refractory Bell's Palsy

Bell's palsy (BP) is characterized by idiopathic acute weakness of the facial muscles associated with compression of the facial nerve. The present prospective study sought to evaluate the clinical efficacy of ultrasound-guided combined perineural and intramuscular dextrose injection for management of refractory Bell's palsy. The study included 30 patients with Bell's palsy with House-Brackmann scale ≥ 3 who were refractory to standard medical treatment after 3 months of disease onset. They received ultrasound-guided combined perineural and intramuscular dextrose injection. Clinical outcome was assessed using the House-Brackmann scale.

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Key information

Conditions

Bell Palsy Cranial Nerve Diseases DNA Virus Infections Facial Nerve Diseases Herpesviridae Infections Infections Mouth Diseases Nervous System Diseases Stomatognathic Diseases Virus Diseases

Age range

Up to 18 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Primary location

Al-Azhar University Hospital

Cairo, 247883, Egypt

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

The study included 30 patients with Bell's palsy diagnosed according to the recommendations of American Academy of Otolaryngology-Head and Neck Surgery Foundation

Exclusion criteria

Patients were excluded if they were previously submitted to injection therapy or surgical intervention for management of Bell's palsy. They were also excluded if they had associated mental illness or advanced systemic conditions (e.g. uncontrolled diabetes, uncontrolled hypertension, malignant disease, immunocompromised conditions).

Treatment and study plan

Ultrasound-guided combined perineural and intramuscular dextrose injection.

Procedure

Ultrasound-guided combined perineural and intramuscular dextrose injection.

Primary outcomes

House Brackmann scale

Time frame: 3 months

House Brackmann scale

Sponsors and collaborators

Lead sponsor

Al-Azhar University

Other

Registry information

Official study title

Ultrasound-guided Combined Perineural and Intramuscular Dextrose Injection for Management of Refractory Bell's Palsy A Prospective Study

Important dates

Study start: 2025
Primary completion: 2026
Study completion: 2026
First posted: Jul 27, 2026
Registry last updated: Jul 27, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed