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NCT Number: NCT07063147

TTE Improves Clinical Management of Stable Chest Pain

The investigator aims to prospectively enroll patients who were referred for transthorcic echocardiography (TTE) for the assessment of stable chest pain (SCP) suspected of obstructive coronary artery disease (CAD). All patients underwent TTE according to established guidelines and local institutional protocols. This study will determine if TTE-based imaging evaluation can provide more informaton to improve clinical management for SCP, including fewer MACE and better decision-making of downstream investigations and therapeutic interventions.

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Key information

Conditions

Transthorcic Echocardiography Angina Pectoris Angina, Stable Arterial Occlusive Diseases Arteriosclerosis Cardiovascular Diseases Chest Pain Coronary Artery Disease Coronary Disease Heart Diseases Invasive Coronary Angiography Major Adverse Cardiac Events Myocardial Ischemia Neurologic Manifestations Pain Pathological Conditions, Signs and Symptoms Signs and Symptoms Stable Angina Pectoris Vascular Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • symptomatic patients with SCP suspected of obstructive CAD.
  • referred for TTE for the assessment of SCP.
  • ≥18 years of age.
  • signed informed consent.

Exclusion criteria

  • acute coronary syndromes
  • previous CAD or coronary revascularization
  • nonsinus rhythm
  • cardiomyopathy, valvular disease, congenital heart disease or left cardiac insufficiency because of other reasons

Treatment and study plan

TTE

Diagnostic Test

All patients underwent TTE according to established guidelines and local institutional protocols. The imaging data were evaluated using different image post-processing software to comprehensively analyse anatomical, functional and histological information of coronary.

Primary outcomes

  1. Major adverse cardiovascular events

    Time frame: 10 years

Secondary outcomes

  1. Invasive coronary angiography

    Time frame: 10 years

    Invasive coronary angiography occurred at follow-up after TTE, attributed to TTE results or unplanned.

  2. Medication prescription

    Time frame: 10 years

    Change for medication prescription of antiplatelet agents, anti-ischemic drugs, lipid-lowering agents, angiotensin-converting enzyme inhibition and so on, attributed to TTE results or unplanned,

  3. Coronary revascularization

    Time frame: 10 years

    PTCA, PCI or CABG occurred at follow-up after TTE, attributed to TTE results or unplanned.

Study contacts

Contact information is provided by the study sponsor or research team.

Jia Zhou

CONTACT

[email protected]

+8615522485560

Sponsors and collaborators

Lead sponsor

Tianjin Chest Hospital

Other

Registry information

Official study title

Improving the Clinical Management of Stable Chest Pain Based on Imaging: a Registry of Transthorcic Echocardiography

Acronym: TICM-SCP

Important dates

Study start
2025
Primary completion
2030
Study completion
2040
First posted
Jul 14, 2025
Registry last updated
Jul 18, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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