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NCT Number: NCT06917378

TRIO CTO (Taiwan Research Initiative on Coronary Total Occlusion)

Coronary chronic total occlusions (CTO) present a significant challenge in the field of interventional cardiology. These complex lesions, characterized by complete blockage of a coronary artery for a prolonged duration, often require specialized techniques and strategies to achieve successful revascularization.

Recruiting

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Key information

Age range

20 year–120 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Chang Gung Memorial Hospital, New Taipei City, Taiwan

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About this study

Using this consortium, we will establish a multicenter cohort to evaluate the clinical parameters, angiographic characteristics, interventional techniques, and clinical outcomes involved in coronary CTO intervention. 3 subprojects are listed here.

Subproject 1 intends to develop a novel algorithm integrating antegrade and retrograde scoring system to optimize the CTO intervention and determine the optimal timing for primary retrograde approach. Current algorithm for CTO intervention.

Subproject 2 aims to examine the strategies and outcomes of CTO involving bifurcations. Bifurcation CTO lesions present unique challenges due to their complex anatomy. Opening of the main vessel while preserving important branches is crucial for ensuring favorable long-term clinical prognosis. This subproject will investigate different strategies and devices employed in bifurcation CTO PCI to assess their efficacy and safety outcomes.

Subproject 3 investigates the treatment strategies for right coronary artery (RCA) CTOs with concomitant left main disease, which present a unique and intricate scenario, requiring careful consideration of revascularization strategies.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Over 20 years old
  • Chronic total occlusion confirmed by coronary angiography, and noted for more than 3 months

Exclusion criteria

Nil

Treatment and study plan

Percutaneous coronary intervention of coronary chronic total occlusion

Procedure

Coronary CTO was identified by coronary angiography, and its revascularization was attempted by either antegrade, retrograde or both approach.

Other names: PCI to CTO

Primary outcomes

  1. Number of participants with technical success of CTO revascularization

    Time frame: 1 day

    Successful CTO recanalization with <20% residual stenosis within the treated segment and restoration of Thrombolysis in Myocardial Infarction grade 3 antegrade flow, without side branch loss

  2. Number of participants with collateral channel tracking success

    Time frame: 1 day

    retrograde guidewire crossing the CC to reach the distal cap of CTO segment.

  3. Number of participants with major adverse cerebral cardiovascular events

    Time frame: 5 years

    Death, CV death, myocardial infarction, stroke, repeat revascularization

Secondary outcomes

  1. Number of participants with periprocedural myocardial infarction

    Time frame: 1 day

    Confirmed by

  2. Number of participants with periprocedural complications

    Time frame: 1 day

    Periprocedural myocardial infarction, vessel perforation, stroke, urgent or emergent revascularization

Study contacts

Contact information is provided by the study sponsor or research team.

Chih Fan Yeh

CONTACT

[email protected]

+8862-23123456 ext. 263912

Sponsors and collaborators

Lead sponsor

National Taiwan University Hospital

Other

Collaborators

  • Chang Gung Memorial Hospital
  • Taipei Veterans General Hospital, Taiwan

Registry information

Official study title

The Multicenter Study to Evaluate Clinical and Angiographic Factors in Patients With Coronary Artery Chronic Total Occlusion in Taiwan

Important dates

Study start
2017
Primary completion
2034
Study completion
2034
First posted
Apr 8, 2025
Registry last updated
Dec 18, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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