Skip to main content
OpenTrials
Completed

NCT Number: NCT01143974

Trial of Pemetrexed in Combined With Cisplatin for the Treatment of Advanced Breast Cancer

For patients resistant to enthrycycline and taxanes, there is no standard regimen. Pemetrexed alone had certain efficacy in treatment of advance breast cancer. Platin was also a effective drug for advanced breast cancer. The combination of these two drug may have a synergy with each other in treatment of advanced breast cancer.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Locally Advanced Malignant Neoplasm

Age range

18 year–70 year

Sex eligibility

Female

Study type

Interventional

Phase

Phase 4

Primary location

Cancer Institute & Hospital. Chinese Academy of Medical Sciences

Beijing, 100021, China

About this study

combination of pemetrexed and cisplatin to treat advanced breast cancer. Previous regimen no more than 3 which including enthrycycline and taxanes(paclitaxel and/or docetaxel)

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • 18-70 years old
  • Resistant to enthracycle and taxanes
  • Has measurable disease

Exclusion criteria

  • Has more than 3 previous chemotherapy regimens

Treatment and study plan

pemetrexed plus cisplatin

Drug

pemetrexed 500mg/m2 plus cisplatin 80mg/m2 on day1 of each 21 day cycle, until progression

Other names: Alimta

Primary outcomes

  1. PFS (progression free survival)

    Time frame: 2 Years

Secondary outcomes

  1. Safety

    Time frame: 2 years

    Assessing for Hematology and Non-hematology toxicities, including all SAEs.

  2. Response Rate

    Time frame: 2 years

Sponsors and collaborators

Lead sponsor

Chinese Academy of Medical Sciences

Other

Registry information

Important dates

Study start
2010
Primary completion
2012
Study completion
2012
First posted
Jun 15, 2010
Registry last updated
Mar 14, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.