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Completed

NCT Number: NCT03823794

Trends in the Epidemiology and Treatment of Atopic Dermatitis in the United Kingdom (UK)

Atopic dermatitis (AD), commonly called eczema, is one of the most frequently occurring skin conditions. It is estimated to affect around one fifth of children in developed countries and is also becoming increasingly common in less developed countries. Exact estimates of how common eczema is, vary considerably and there has not been an in-depth analysis of the number of people with eczema in the UK. It is also unclear which groups of people are most affected and which treatment options are being used.

Most people with eczema are managed by their general practitioner (GP) with only a few people requiring specialist care. GP records therefore provide an excellent opportunity to explore how common eczema is and which treatments are being used currently.

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Key information

Conditions

Atopic Dermatitis Eczema Atopic Dermatitis Congenital, Hereditary, and Neonatal Diseases and Abnormalities Dermatitis Dermatitis, Atopic Eczema Genetic Diseases, Inborn Hypersensitivity Hypersensitivity, Immediate Immune System Diseases Skin Diseases Skin Diseases, Eczematous Skin Diseases, Genetic Skin and Connective Tissue Diseases

Age range

0 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Momentum Data Ltd

London, WC1X 8QT, United Kingdom

About this study

Objective

The study aims to describe the health care resource utilisation of patients with active AD in terms of prescription use, primary care appointments, and specialist referrals.

Method This study will define AD cases using a previously validated algorithm for case identification use clinical codes form primary care in the UK (Read codes). The study will analyse a cohort of prevalent active AD cases over a one year period (2018). The annual use of topical and oral medications used for the treatment of AD, primary care appointments, and specialist referrals will be reported.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • All paediatric and adult patients registered with an Royal College of General Practitioners (RCGP) Research and Surveillance Centre (RSC) contributing GP practice during the study period (2008-2018) and with at least one year of follow-up.

Exclusion criteria

  • The presence of psoriasis, photodermatitis, or ichthyosis

Treatment and study plan

No intervention

Other

Observational analysis of usual care only

Primary outcomes

  1. Prescription Rates for Atopic Dermatitis Related Treatments: Emollients and Soap Substitutes

    Time frame: Jan - Dec 2018 inclusive

    Proportion of the arm/group receiving at least one prescription for emollients and soap substitutes.

  2. Prescription Rates for Atopic Dermatitis Related Treatments: Mild Topical Corticosteroids (TCS)

    Time frame: Jan - Dec 2018 inclusive

    Proportion of the arm/group receiving at least one prescription for mild topical corticosteroids (atopic dermatitis related treatment)

  3. Prescription Rates for Atopic Dermatitis Related Treatments: Moderate Topical Corticosteroids (TCS)

    Time frame: Jan - Dec 2018 inclusive

    Proportion of the arm/group receiving at least one prescription for moderate topical corticosteroids (an atopic dermatitis related treatment)

  4. Prescription Rates for Atopic Dermatitis Related Treatments: Potent Topical Corticosteroids (TCS)

    Time frame: Jan - Dec 2018 inclusive

    Proportion of the arm/group receiving at least one prescription for potent topical corticosteroids (an atopic dermatitis related treatment)

  5. Prescription Rates for Atopic Dermatitis Related Treatments: Very Potent Topical Corticosteroids (TCS)

    Time frame: Jan - Dec 2018 inclusive

    Proportion of the arm/group receiving at least one prescription for very potent topical corticosteroid (an atopic dermatitis related treatment)

  6. Prescription Rates for Atopic Dermatitis Related Treatments: Topical Calcineurin Inhibitors (TCI)

    Time frame: Jan - Dec 2018 inclusive

    Proportion of the arm/group receiving at least one prescription for a topical Calcineurin Inhibitor (an atopic dermatitis related treatment)

  7. Prescription Rates for Atopic Dermatitis Related Treatments: Topical Antimicrobials

    Time frame: Jan - Dec 2018 inclusive

    Proportion of the arm/group receiving at least one prescription for topical antimicrobials.

  8. Prescription Rates for Atopic Dermatitis Related Treatments: Antihistamin

    Time frame: Jan - Dec 2018 inclusive

    Proportion of the arm/group receiving at least one prescription for antihistamin.

  9. Prescription Rates for Atopic Dermatitis Related Treatments: Systemic Immuno-modulatory Therapy

    Time frame: Jan - Dec 2018 inclusive

    Proportion of the arm/group receiving at least one prescription for Systemic immuno-modulatory therapy

  10. Prescription Rates for Atopic Dermatitis Related Treatments: Oral Corticosteroids

    Time frame: Jan - Dec 2018 inclusive

    Proportion of the arm/group receiving at least one prescription for oral corticosteroids

  11. Specialist Referrals

    Time frame: Jan - Dec 2018 inclusive

    Specialist dermatology referral rate in 2018

  12. Primary Care Referrals

    Time frame: Jan - Dec 2018 inclusive

    Annual rate of primary care consultations in 2018

Sponsors and collaborators

Lead sponsor

Momentum Data

Industry

Collaborators

  • Oxford Royal College of General Practitioners Research and Surveillance Centre
  • Pfizer

Registry information

Official study title

The Epidemiology of Atopic Dermatitis, Associated Comorbidities, and Treatment Patterns in the United Kingdom (UK)

Important dates

Study start
2019
Primary completion
2020
Study completion
2020
First posted
Jan 30, 2019
Registry last updated
Jun 6, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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