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OpenTrials
Completed

NCT Number: NCT07030244

Treatment Outcomes and Predictive Factors of the Effectiveness and Adherence of Moodpep: an Online Self-help Intervention for College Students With Depressive Symptoms

Depressive symptoms are prevalent among college students and often remain untreated. E-health interventions may help overcome treatment barriers by offering accessible and flexible support. This study will evaluate the effects of Moodpep, a guided online intervention for college students with depressive symptoms, and will examine predictors of treatment success and adherence.

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Key information

Age range

16 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

VU Amsterdam, Amsterdam, Netherlands

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Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Eligible for Moodpep were students from the participating universities and universities of applied sciences: VU Amsterdam, Leiden University, Maastricht University, Utrecht University, Erasmus University Rotterdam, University of Amsterdam, InHolland University of Applied Sciences, Avans University of Applied Sciences and Rotterdam University of Applied Sciences.

The following inclusion criteria for Moodpep were used:

  • age 16 or older;
  • informed consent was provided;
  • reading Dutch and/or English fluently;
  • having access to a device with internet (e.g., computer, laptop);
  • providing complete data at baseline; and
  • no severe depressive symptoms (PHQ-9 total score > 20) or risk of suicidal behavior (based on 3 questions).

This last criterion was removed on May 9, 2023. After data collection, for statistical and content-related reasons, PhD students were removed from the analysis, just as students below 18 and above 30 years old, students who indicated their gender was other and students who completed less than 1 module of the intervention. This was done because the focus of the study was on students and not PhD students who are employees in the Netherlands, most students are between 18 and 30 years old, not enough students of another gender participated to include them separately in the analyses, and we were interested in the effects of Moodpep for students who started the intervention.

Treatment and study plan

Moodpep

Behavioral

See arm description

Primary outcomes

  1. Depressive symptoms (PHQ-9)

    Time frame: T0 (baseline), T1 (6 weeks post-baseline), T2 (6 months post-baseline)

    Patient Health Questionnaire-9 (PHQ-9; Kroenke et al., 2001). Total scores range from 0 to 27 with higher scores indicating more depressive symptoms.

Secondary outcomes

  1. Adherence

    Time frame: T1 (6 weeks post-baseline)

    Number of modules completed (1-8). For the logistic regression analysis, 2 categories will be made: participants who completed 1 module and participants who completed 2-8 modules.

  2. Predictors

    Time frame: T0 (baseline)

    Age, gender (male, female), nationality (Dutch, international), current psychotropic medication use (yes, no), and current psychotherapy (yes, no).

Sponsors and collaborators

Lead sponsor

Universiteit Leiden

Other

Collaborators

  • Avans University of applied sciences
  • Erasmus University Rotterdam
  • InHolland University of Applied Sciences
  • Maastricht University
  • Rotterdam University of Applied Sciences
  • University of Amsterdam
  • Utrecht University
  • VU University of Amsterdam

Registry information

Important dates

Study start
2020
Primary completion
2024
Study completion
2024
First posted
Jun 22, 2025
Registry last updated
Jun 27, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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