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NCT Number: NCT06675578

Treatment of Periodontitis by Tulsi Gel

This study will be carried out to compare between the effect of 4%Tulsi gel and 1%Chlorohexidine gel as locally administered agents in the treatment of advanced periodontitis. Clinical parameters measurements, microbiological and radiographic assessment will be performed at base line, one month and 3 months after the intervention.

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Key information

Conditions

Advanced Periodontitis Mouth Diseases Periodontal Diseases Periodontitis Stage III Periodontitis Stage IV Periodontitis Stomatognathic Diseases

Age range

30 year–50 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 2 / Phase 3

Primary location

Faculty of Dentistry, Al-Azhar university

Cairo, Egypt

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • All patients included in this study will be having advancedI Periodontitis
  • Aging from 30 to 50 years old
  • Free from any local or systemic risk factors that may affect the results of the study.

Exclusion criteria

  • Long-term therapy with medications within a month prior to enrollment that could affect periodontal status or healing.
  • Pregnant woman and lactating mothers.
  • Patients with previous periodontal treatment including scaling and root planning and periodontal surgery in the last 3 and 6 months, respectively.

Treatment and study plan

Tulsi gel

Drug

After scaling and root debridement, 4% of Tulsi gel will be injected in to the sulcus until it over flooded, at base line, then after one month.

Other names: Basil gel

chlorhexidine gel

Drug

After scaling and root debridement, 1% of Chlorhexidine gel will be injected in to the sulcus until it over flooded, at base line, then after one month.

Other names: Corsodyl 1% w/w dental gel

Primary outcomes

  1. Clinical parameters

    Time frame: 3 months after end of treatment

    Improvement of the clinical attachment loss in millimeters.

  2. Clinical parameters

    Time frame: 3 months after end of treatment

    Improvement of gingival index.

  3. Clinical parameters

    Time frame: 3 months after end of treatment

    Improvement of probing depth in millimeters.

Secondary outcomes

  1. Microbiological assessment

    Time frame: 3 months after end of treatment

    Counting microbial colony of Porphyromonas gingivalis

  2. Microbiological assessment

    Time frame: 3 months after end of treatment

    Counting microbial colony of Fusobacterium nucleatum

  3. Microbiological assessment

    Time frame: 3 months after end of treatment

    Counting microbial colony of Tannerella forsythia

Sponsors and collaborators

Lead sponsor

Al-Azhar University

Other

Registry information

Official study title

Non Surgical Treatment Using Tulsi Gel Versus Chlorhexidine Gel as Adjunctive in Treatment of Advanced Periodontitis ( Stage III and Stage IV )

Important dates

Study start
2025
Primary completion
2025
Study completion
2025
First posted
Nov 5, 2024
Registry last updated
Jul 1, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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