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NCT Number: NCT07671274

Comparison of the Efficacy of Conventional Versus Minimally Invasive Non-Surgical Periodontal Therapy in Periodontitis Patients

the aim of this study is to investigate the clinical outcomes of Minimally Invasive Non-Surgical Therapy(MINST) compared to Conventional non-surgical periodontal therapy (CNST)

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Key information

Age range

20 year–40 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Early Phase 1

Primary location

Mansoura university Faculty of dentistry

Al Mansurah, Dakhlia, 00000, Egypt

Location status: Recruiting

Location contact

fatma saad elsherbini, phd

CONTACT

[email protected]

+201128065677

About this study

A total of thirty patients were included in the study, Inclusion Criteria: -

  • Patients with stage III pericdontitis, according to the American Academy of Periodontology (AAP) and the European Federation of Periodontology (EFP) periodontal classification system .
  • Medically free patients.
  • Non-smokers
  • Patients with good oral hygiene. Exclusion Criteria: -
  • Pregnant or lactating females.
  • Patients with systemic diseases that might affect periodontal health
  • previous periodontal treatment within 6 months before baseline examination.
  • prior antibiotic regimen use within 1 month before baseline examination All participants will receive oral hygiene instructions including toothbrushin, interdental cleaning, and plaque control behavior reinforcement with oral hygiene self-care regimens to be followed at home.
  • On the conventional non-surgical periodontal therapy side, a power-driven piezo•electric ultrasonic scaling device with scaling tips will be used the majority of the time to debride subgingival biofilm and calculus. and manual standard gracey curette instruments will be used to refine residuals from root surfaces.
  • Conversely, the treatment protocol of the minimally invasive non-surgical periodontal therapy side will be followed as in the previous study (5).
  • Briefly. the root surface of teeth will be thoroughly debrided by a minimally invasive approach using specific thin and delicate piezo-electric scaling tips (Woodpecker � Tip P3. Am Perfect sp. z o .• � Poland) and manual miniature periodontal curettes {� Dent Solutions. Cairo. Egypt) for reducing periodontal tissue trauma. Adjunctive use of magnification loupes will be performed.
  • Both modalities will be performed under local anesthesia.
  • All patients will be recalled 1 and 3 months after tre.alment for re-ev.almtion and professional supra-gingival plaque control

study parameters are plaque index bleeding of probing periodontal pocket depth clinical attachment loss gingival index

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • • Patients with stage III pericdontitis, according to the American Academy of Periodontology (AAP) and the European Federation of Periodontology (EFP) periodontal classification system .
  • Medically free patients.
  • Non-smokers
  • Patients with good oral hygiene.

Exclusion criteria

  • Pregnant or lactating females.
  • Patients with systemic diseases that might affect periodontal health
  • previous periodontal treatment within 6 months before baseline examination.
  • prior antibiotic regimen use within 1 month before baseline examination

Treatment and study plan

Mechanical debridement .

Device

On the conventional non-surgical periodontal therapy side, a power-driven piezo•electric ultrasonic scaling device with scaling tips will be used the majority of the time to debride subgingival biofilm and calculus. and manual standard gracey curette instruments will be used to refine residuals from root surfaces.

minimally invasive mechanical debridement

Device

Briefly. the root surface of teeth will be thoroughly debrided by a minimally invasive approach using specific thin and delicate piezo-electric scaling tips (Woodpecker � Tip P3. Am Perfect sp. z o .• � Poland) and manual miniature periodontal curettes {� Dent Solutions. Cairo. Egypt) for reducing periodontal tissue trauma. Adjunctive use of magnification loupes will be performed.

Primary outcomes

  1. Plaque index (PI)

    Time frame: basline, 1 month , 3 months

    • Plaque index (PI):The index assigns a score to each tooth based on the amount of plaque present.

    0: No plaque is visible.

    • A thin film of plaque is present at the gingival margin (gumline) and can be detected with a probe.
    • Visible plaque along the gingival margin.
    • Heavy plaque accumulation in the gingival margin and interdental spaces.
  2. Bleeding on probing (BOP):

    Time frame: baseline, 1 month , 3 months

    ): "0" if no bleeding occurred within 10 second, and "1" if there was bleeding within 10 second.

  3. Probing pocket Depth (PPD)

    Time frame: baseline , 1 month , 3 month

    ): will be measured from the gingival margin to the base of the periodontal pocket.

  4. Clinical Attachment Level (CAL)

    Time frame: baseline ,1 month , 3 month

    will be measured from the cement-enamel junction to the base of the periodontal pocket.

Study contacts

Contact information is provided by the study sponsor or research team.

fatma saad elsherbini, phd

CONTACT

[email protected]

+201128065677

Sponsors and collaborators

Lead sponsor

Mansoura University

Other

Registry information

Official study title

Comparison of the Efficacy of Conventional Versus Minimally Invasive Non-Surgical Periodontal Therapy in Periodontitis Patients (Randomized Controlled Clinical Trial)

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Jun 26, 2026
Registry last updated
Jun 26, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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