Treatment of Low Locally Advanced Rectal Cancer With Radiotherapy Removal TNT Plus Neoadjuvant Therapy

Inclusion criteria

• Aged between 18 and 70;
• Histologically confirmed adenocarcinoma of rectum;
• The distance from the lower edge of the tumor to the anus is ≤ 10cm;
• ECOG score ≤ 1;
• Have not received any anti-tumor treatment before;
• Preoperative abdominal enhanced CT or MRI showed cT4, cN0-2; M0 chest and abdomen CT showed no obvious metastasis. (Note: PET-CT is recommended when small nodules can not be identified by liver or lung CT, and can still be included in the group when considering the possibility of metastasis)
• Hematological indicators and liver and kidney function within 7 days are within the normal range;
• Sign the informed consent form and be able to follow the research and /or follow-up procedures.

Exclusion criteria

• Have serious basic diseases, such as heart disease, renal failure, severe liver failure or liver failure, coagulation dysfunction, etc; Postoperative recurrence of colorectal cancer;
• The patient had a history of malignant tumor within 5 years;
• Pregnant or lactating women;
• The patient has a history of adjuvant radiotherapy for other system diseases, and surgical contraindications, so it is not suitable for surgery;
• The patient has had radiotherapy and chemotherapy records before this visit;
• Distant metastasis was found during operation;
• Patients with poor radiotherapy compliance and difficult cooperation;