Treatment of Local Gingival Recession With an Enamel Matrix Protein Coated Collagen Matrix

The study aims to evaluate the influence of the additional use of EMD in treatment of gingival recession defects using a coronally advance flap (CAF) and a CM (collagen matrix) by means of digital and clinical assessment methods. The reference group comprises patients receiving treatment with CAF and CM without the application of EMD.

In this prospective, randomized, controlled study, recession height and area, width and thickness of keratinized gingiva, pocket probing depth, and the clinical attachment level were measured at baseline and followed-up for one year.

15 patients with 24 gingival recession defects (Recession Type 1 after Cairo/Miller Class I or II) were recruited and were randomly assigned into the two treatment groups.

Inclusion criteria

• Signed Informed Consent
• able to achieve good oral hygiene (full mouth plaque score < 20 %, full mouth bleeding score < 20%),
• patients presenting with at least one gingival recession defect

Exclusion criteria

• general contraindications to dental surgery under local anaesthesia (e.g., severe systemic diseases, tumours, severe cardiovascular diseases, uncontrolled diabetes mellitus);
• ongoing or previous chemotherapy, radiotherapy, or bisphosphonate therapy;
• self-reported heavy smokers (more than 10 cigarettes/day);
• pregnancy and nursing mothers;
• disorders or treatments that impair wound healing;
• long-term treatment with high-dose steroids or anticoagulants;
• bone metabolism disorders;
• infections or vascular disorders in the region to be treated;
• known hypersensitivity to porcine collagen;
• patients with severe peripheral artery disease or autoimmune diseases;
• extruded or malpositioned teeth.