Hyaluronic Acid With Connective Tissue Grafting for Gingival Recession

This study evaluates whether adding 0.8% hyaluronic acid (HA) to connective tissue grafting and coronally advanced flap surgery improves clinical and esthetic outcomes in the treatment of gingival recession. Adult patients with Miller I-II or Cairo RT1 recession defects will be randomly assigned to receive CTG alone or CTG with adjunctive HA. Mean root coverage at 6 months is the primary outcome, while secondary measures include gingival thickness, clinical attachment level, esthetic scores, postoperative morbidity, and quality of life. The study aims to determine whether HA enhances soft tissue healing and root coverage predictability compared with conventional CTG.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Gingival Recession Gingival Diseases Mouth Diseases Periodontal Atrophy Periodontal Diseases Stomatognathic Diseases

Age range

18 month and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University of Health Sciences, Gülhane Faculty of Dentistry

Ankara, None Selected, 6220, Turkey (Türkiye)

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Presence of at least one gingival recession defect classified as Cairo RT1 or Miller Class I-II with a minimum depth of 1 mm.
Full-mouth plaque score (FMPS) and full-mouth bleeding on probing (FMBOP) < 15%.
Detectable cemento-enamel junction (CEJ).
Age ≥ 18 years.
No history of prior periodontal surgical treatment.
Sufficient mental capacity to understand the study aims and procedures explained verbally and in writing.
Determined to be cooperative and compliant with the clinician before, during, and after the surgical procedure.

Exclusion criteria

Patients younger than 18 years.
Periodontally healthy individuals.
Current smokers.
History of periodontal treatment within the past 1 year.
Use of antibiotics within the past 3 months.
Pregnancy or breastfeeding.
Presence of systemic diseases such as diabetes, chronic kidney failure, cancer, bleeding disorders, connective tissue diseases, or other chronic conditions; and gingival recessions classified as Cairo RT3.
Presence of cervical caries or restorations at the defect site.

Treatment and study plan

Hyaluronic Acid (0.8%) - Applied over CTG before flap closure (Test group only).

Biological

A 0.8% hyaluronic acid (HA) gel is applied to the connective tissue graft (CTG) before flap closure during the coronally advanced flap (CAF) procedure. The HA gel is used as an adjunctive biologic material to potentially enhance wound healing, soft tissue thickness, esthetic outcomes, and overall root coverage performance

Connective Tissue Graft + Coronally Advanced Flap (CTG + CAF)

Procedure

A standardized coronally advanced flap (CAF) procedure combined with a subepithelial connective tissue graft (CTG) is performed to treat gingival recession defects. The surgical protocol includes flap elevation, graft harvesting and placement, and flap advancement and suturing.

Primary outcomes

Impact of Adjunctive Hyaluronic Acid on Mean Root Coverage After Recession Treatment

Time frame: From enrollment to the end of treatment at 6 months"

The primary objective of this study is to evaluate the effect of adjunctive hyaluronic acid (HA) on the mean root coverage (MRC) achieved after the treatment of gingival recession defects.

Sponsors and collaborators

Lead sponsor

Saglik Bilimleri Universitesi

Other

Registry information

Official study title

Clinical and Aesthetic Evaluation of Hyaluronic Acid in Addition to Connective Tissue Grafts in the Treatment of Gingival Recession Defects

Important dates

Study start: 2025
Primary completion: 2026
Study completion: 2026
First posted: Dec 18, 2025
Registry last updated: Jul 21, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed