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Completed

NCT Number: NCT02798016

Treatment of Atrophic Acne Scars With Platelet-Rich Plasma and Skin Needling

Investigators will collect blood specimens from the participating patients and then blood samples will be centrifuged in order to collect platelet-rich plasma which is going to be injected in the atrophic acne scars. A split-face design is going to used in this randomized controlled trial. In the control side of the face, micro-needling to the skin will occur using a specific tool (Dermapen).

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Key information

Conditions

Atrophic Acne Scars

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Department of Dermatology and Venereology

Damascus, Syrian Arab Republic, DM20AM18, Syria

About this study

Atrophic acne scar is a common problem with a challenging treatment. Platelet-rich plasma (PRP) is an autologous preparation of platelets in concentrated plasma that may be beneficial in the treatment of atrophic acne scars by promoting collagen deposition.

Skin needling is a technique that uses a sterile micro needles to puncture the skin and release growth factors. The combination of skin needling and PRP could enhance the efficacy of both modalities.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Atrophic acne scars on both sides of the face

Exclusion criteria

  • patients with active acne, herpes labialis, or bacterial infection; warts on the face, actinic keratosis, or skin cancer
  • systemic retinoids intake in the previous 6 months,
  • diabetes, pregnancy, history of keloidal scarring; or patients with severe systemic illness or malignancy
  • patients on anticoagulant therapy or aspirin or have a coagulation issue,
  • patients with hemoglobin less than 10g\\dl or platelet less than 105 micron\\l
  • any previous procedures for acne scar within the last 6 months

Treatment and study plan

platelet-rich plasma

Procedure

This Platelet-Rich Plasma will be taken from each patient and is going to be used in the treatment of atrophic acne scars

Micro-needling

Procedure

Micro-needling will be applied on the acne scars in one side of the face.

Primary outcomes

  1. Change in Scar Appearance

    Time frame: Scar Appearance will be assessed at: T1; one day (wihtin 24 hours) before the application of the intervention(s); and T2: after three months of applying the intervention(s).

Secondary outcomes

  1. Patients' Satisfaction

    Time frame: This is going to be assessed six months following the application of the intervention and the active comparator

    The assessment will be based on a questionnaire

Sponsors and collaborators

Lead sponsor

Damascus University

Other

Registry information

Official study title

Treatment of Atrophic Acne Scars With Platelet-Rich Plasma Alone or in Combination With Skin Needling: A Randomized Controlled Trial

Important dates

Study start
2015
Primary completion
2017
Study completion
2017
First posted
Jun 14, 2016
Registry last updated
Jan 3, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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