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NCT Number: NCT03843580

Transnasal Humidified Rapid-Insufflation Ventilatory Exchange (THRIVE) Could Decrease the Incidence of Oxygen Desaturation During Suspension Laryngoscopy: a Randomized Controlled Trial (Optilaryngo)

Suspension laryngoscopy is realised during apnea. In effect, surgeons are in the mouth of the patient and we can't have access at the aiways.

So investigators like to use a Transnasal Humidified Rapid-Insufflation Ventilatory Exchange (THRIVE) to increase time of apnea and decrease the impact of oxygen desaturation.

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Key information

Conditions

Apnea, Postanesthetic Anesthesia Apnea Butyrylcholinesterase deficiency Congenital Abnormalities Congenital, Hereditary, and Neonatal Diseases and Abnormalities Desaturation of Blood Laryngeal Diseases Larynx Disease Otorhinolaryngologic Diseases Pathological Conditions, Signs and Symptoms Pharynx; Anomaly Respiration Disorders Respiratory Tract Diseases Signs and Symptoms Signs and Symptoms, Respiratory

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

CaenUH, Caen, Normandy, France

Loading trial locations.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • suspension laryngoscopy

Exclusion criteria

  • THRIVE contraindication:
  • epistaxis
  • undrained pneumothorax
  • Recent gastroesophageal surgery (1months)
  • Skull Fractures

Treatment and study plan

Optiflow

Device

we use Transnasal Humidified Rapid-Insufflation Ventilatory Exchange (thrive-optiflow) during general anesthesia for suspension laryngoscopy

Primary outcomes

  1. desaturation defined as the number of patient who presented at least one desaturation during suspension laryngoscopy

    Time frame: Two hours

    the number of patient who presented at least one desaturation during suspension laryngoscopy. An oxygen desaturation define like SpO2<96%

Secondary outcomes

  1. hypoxemia (decrease the number of Hypoxemia event define like SpO2<90%)

    Time frame: 2 hours

    Decrease the number of Hypoxemia event define like SpO2<90%

  2. side effect

    Time frame: 2 hours

    decrease the number of side effects

Other outcomes

  1. time of apnea

    Time frame: 2 hours

    increase time of apnea with THRIVE

Sponsors and collaborators

Lead sponsor

University Hospital, Caen

Other

Collaborators

  • Centre Francois Baclesse

Registry information

Official study title

Transnasal Humidified Rapid-Insufflation Ventilatory Exchange (THRIVE) Could Decrease the Incidence of Oxygen Desaturation During Suspension Laryngoscopy: a Randomized Controlled Trial

Acronym: optilaryngo

Important dates

Study start
2019
Primary completion
2021
Study completion
2022
First posted
Feb 18, 2019
Registry last updated
Feb 18, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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