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OpenTrials
Completed

NCT Number: NCT03428165

Transfer of Frozen Embryos in Natural Cycle: Evaluation of Impact of Spontaneous Versus HCG-triggered Ovulation on Pregnancy Rate

The purpose of the study is to evaluated whether there is a difference in pregnancy rate when transferring frozen embryos between patietns having spontaneously ovulated versus those triggered to voulate with HCG.

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Key information

Conditions

In Vitro Fertilization

Age range

18 year–40 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

CHU Arnaud de Villeneuve, Montpellier, France

Loading trial locations.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • The patient must have given their free and informed consent and signed the consent form
  • The patient must be a member or beneficiary of a health insurance plan
  • The patient is aged between 18 and 40
  • Patient has regular cycles and classified as 'easy' for transfer of a frozen embryo at blastocyste stage (vitrification day 5)

Exclusion criteria

  • The subject is participating in an interventional study, or is in a period of exclusion determined by a previous study
  • The subject refuses to sign the consent
  • It is impossible to give the subject informed information
  • The patient is under safeguard of justice or state guardianship
  • Patient using donated oocytes
  • Necessity of pre-implantation diagnosis
  • Patients with stage 3 or 4 endometriosis or adenomyosis

Treatment and study plan

HCG

Other

250 μg/0.5ml choriogonadotropine alpha, Ovitrelle, Merck Serono

Primary outcomes

  1. Pregnancy rate after transfer of frozen embryos at day 14 between groups

    Time frame: Day 14

    Yes/no; Blood ßHCG > 100UI/L

Secondary outcomes

  1. Pregnancy rate at week 12

    Time frame: Week 12

    Yes/no; ultrasound

  2. Miscarriage rate within first 12 weeks

    Time frame: Week 12

    Yes/no; ultrasound

  3. Live birth

    Time frame: At delivery, maximum week 42

    Yes/no

  4. Pregnancy term

    Time frame: At delivery, maximum week 42

    Weeks

  5. Birth weight

    Time frame: At delivery, maximum week 42

    Kg

  6. Cancellation of transfer due to premature ovulation (progesterone >3ng/ml and/or Luteinizing hormone > 3-fold base level)

    Time frame: Day 0

    Yes/no

  7. Number of visits for endometrial preparation until attaining LH peak

    Time frame: Day 0

    Number of visits

Sponsors and collaborators

Lead sponsor

Centre Hospitalier Universitaire de Nīmes

Other

Registry information

Official study title

Transfer of Frozen Embryos in NATural Cycle: Evaluation of Impact of Spontaneous Versus HCG-triggered Ovulation on Pregnancy Rate - Bicentric Prospective Open Randomized Controlled Trial

Acronym: TECNAT

Important dates

Study start
2018
Primary completion
2021
Study completion
2022
First posted
Feb 9, 2018
Registry last updated
Dec 4, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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