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NCT Number: NCT02361827

The Effect of Vitamin D on in Vitro Fertilization Outcome

To date, several studies have been done to explore the relationship between Vitamin D level and IVF outcome; however, the results are controversial. Sample sizes in these studies mentioned above were relatively small. In addition, there are no prospective cohort studies in this field. Thus, here the investigators carry this prospective observational cohort study to demonstrate the relationship between vitamin D level and IVF outcome.

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Key information

Conditions

Ongoing Pregnancy Rate In Vitro Fertilization Vitamin D

Age range

21 year–40 year

Sex eligibility

Female

Study type

Observational

Primary location

Reproductive Medical Center, First Affiliated Hospital of Zhengzhou University

Zhengzhou, Henan, 450052, China

About this study

Vitamin D level is measured before the commence of IVF cycle. According to Vitamin D level, patients are divided into 3 groups: A, Deficient, <20 ng/mL; B, Insufficient, 20-29.9 ng/mL; C, Replete, >30 ng/mL.

Ongoing pregnancy rate are compared among these three groups after controlling age, number of embryos transferred, ect.

In addition, Vitamin D level is also meassured before embryo transfer in FET cycles with PGT treatment. The effect of Vitamin D on IVF outcome is detected in patients transferred with Euploid embryos.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • age between 21-40 years old
  • basal FSH hormone level less than 10 mIU/mL
  • the first cycle of IVF treatment with standard long protocol
  • both ovarian present and normal uterus.

Exclusion criteria

  • Important data missing
  • Gametes donation cycles
  • Anyone that does not meet the inclusion criteria

Treatment and study plan

Embryo transfer

Procedure

For patients in each group after oocyte retrieval, they will have embryo transferred 3 or 5 days after oocyte retrieval. For FET cycles, they will have ET with an euploid blastocyst.

Primary outcomes

  1. Ongoing pregnancy rate

    Time frame: 12 weeks after embryo transfer

    12 weeks after embryo transfer, gestational sac with fetal heart present inside uterus

Secondary outcomes

  1. Ectopic pregnancy rate

    Time frame: 35 days after embryo transfer

    Ectopic pregnancy is defined as serum HCG positive, yet with no gestational sac present inside uterine cavity

Sponsors and collaborators

Lead sponsor

The First Affiliated Hospital of Zhengzhou University

Other

Collaborators

  • Luoyang maternal and child hospital

Registry information

Official study title

The Effect of Vitamin D on in Vitro Fertilization Outcome, a Prospective Observational Study

Important dates

Study start
2018
Primary completion
2022
Study completion
2024
First posted
Feb 12, 2015
Registry last updated
May 27, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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