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Completed

NCT Number: NCT03272412

Serum Progesterone on the Day of Embryo Transfer and Pregnancy Rate.

This study aims to analyze whether serum Progsterone levels on the day of Embryo Transfer are related with Ongoing Pregnancy rate in artificial endometrial preparation cycles with intravaginal micronized progesterone.

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Key information

Conditions

Ongoing Pregnancy Rate

Age range

18 year–50 year

Sex eligibility

Female

Study type

Observational

Primary location

Instituto Valenciano de Infertilidad Spain

Valencia, 46015, Spain

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age <50 years old
  • Hormonal Replacement therapy cycle for embryo transfer in any of the following situations:
  • Embryos in fresh cycle with donated oocytes.
  • Subsequent embryo transfers of vitrified embryos in cycles of donated oocytes.
  • Frozen embryo transfers in cycles with autologous oocytes.
  • Endometrial line: >6.5-7mm (with trilaminar aspect) in proliferative phase, before introducing progesterone.
  • Administration of natural micronized progesterone intravaginally (400 mg/12 hours for 5 complete days (10 dosis), before the embryo transfer and maintained until pregnancy week 12.
  • Embryo transfer of blastocyst (day 5-6).
  • Signed Informed Consent

Exclusion criteria

  • Uterine pathology (submucous o intramural fibroids (>4 cm) or which deform the uterine cavity; endometrial polyps or Müllerian anomalies; or adnexal anomalies (communicating hydrosalpinx).
  • Simultaneous participation in another clinical study.
  • Participation in another clinical study before the inclusion in the present study, and which could affect the objectives of the present study.

Treatment and study plan

Analysis of serum Progesterone in blood sample

Diagnostic Test

Levels of progesterone will be determined on the day of embryo transfer in patients undergoing artificial endometrial preparation cycles.

Primary outcomes

  1. Concentration of serum Progesterone levels

    Time frame: The day of embryo transfer

    Serum progesterone levels

  2. Ongoing Pregnancies depending on Progesterone levels ranges.

    Time frame: Week 5-12 after Embryo Transfer

    Ultrasound to confirm Ongoing Pregnancy

Sponsors and collaborators

Lead sponsor

Instituto Valenciano de Infertilidad, IVI VALENCIA

Other

Registry information

Official study title

Impact of Serum Progesterone Levels on the Day of Embryo Transfer in Artificial Endometrial Preparation Cycles on the Ongoing Pregnancy Rate.

Important dates

Study start
2017
Primary completion
2018
Study completion
2018
First posted
Sep 5, 2017
Registry last updated
Jan 31, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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