Skip to main content
OpenTrials
Completed

NCT Number: NCT00186784

Transcranial Magnetic Treatment (TMS) in Unipolar Depression

Repetitive Transcranial Magnetic Stimulation (rTMS) can improve mood and decrease sadness in patients with depression.

In this study, the investigators seek to increase their understanding about how rTMS improves depression, and to determine which form of rTMS is most effective for depression, when used in combination with antidepressant medication.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Unipolar Depression Depressive Disorder Mental Disorders Mood Disorders

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Early Phase 1

Primary location

St.Joseph's Healthcare, rTMS Laboratory, Mood Disorders Program, 100 West Fifth Street

Hamilton, Ontario, L8N 3K7, Canada

About this study

Patients will be assigned for 4 treatment arms, receiving either left high frequency plus right low frequency, or left high frequency plus right sham, or left sham, plus right low frequency, or left sham plus right sham treatment. All subjects will receive treatments for 10 days and will be followed for another 4 weeks.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Major Depression
  • No physical health problems

Exclusion criteria

  • History of Epilepsy
  • Metal in the head/neck or skull
  • Pacemaker
  • Pregnancy

Treatment and study plan

Transcranial magnetic stimulation (TMS)

Procedure

treatment for 10 days

Primary outcomes

  1. Hamilton Depression Rating Scale

    Time frame: Pre TMS and post TMS

  2. Beck Depression Rating Scale

    Time frame: pre TMS and post TMS

Secondary outcomes

  1. Quantitive Electroencephalographic(QEEG)activity and measures of regional cerebral blood flow

    Time frame: pre TMS and post TMS as well as post phase II, second set of TMS

Sponsors and collaborators

Lead sponsor

St. Joseph's Healthcare Hamilton

Other

Collaborators

  • Queen's University, Kingston, Ontario

Registry information

Official study title

Repetitive Transcranial Magnetic Stimulation (rTMS) in Unipolar Depression

Important dates

Study start
2000
Primary completion
2011
Study completion
2011
First posted
Sep 16, 2005
Registry last updated
Aug 3, 2011

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.