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Completed

NCT Number: NCT01076933

Transcranial Magnetic Stimulation for Borderline Personality Disorder

Primary purpose : to assess the effect on neuropsychological tasks related to planning of 10 daily sessions of right dorsolateral prefrontal cortex with High-frequency repetitive transcranial magnetic stimulation (rTMS) on borderline personality disorder (BPD) patients.

Hypothesis : BPD patients receiving 10 sessions of rTMS will have greater improvement in the average number of move to achieve tasks of the Tower of London, than those receiving sham rTMS.

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Key information

Conditions

Borderline Personality Disorder Mental Disorders Personality Disorders

Age range

20 year–45 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Lionel Cailhol

Toulouse, University Hospital Toulouse, 31059, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • 20 to 45 years old
  • Borderline Personality Disorder (Diagnostic Interview for Borderline Personality Disorder > 8)
  • psychiatric follow-up
  • righthander
  • informed consent
  • affiliated to medical insurance

Exclusion criteria

  • bipolar disorder
  • substance use disorder
  • Major Depressive Disorder or Stress Post Traumatic Disorder
  • history of epilepsy
  • neurosurgery
  • cardiac pacemaker
  • lefthander
  • involuntary admission
  • participation in an other research
  • legal guardianship
  • poor mastery of french.

Treatment and study plan

repetitive Transcranial Stimulation Magnetic (rTMS)

Procedure

The motor threshold was determined in each subject once, before treatment. This was defined as the lowest stimulation intensity capable of inducing a visible movement at least five times out of 10 stimulations. The position of the right dorsolateral prefrontal cortex was defined as 5 cm anterior (in a parasagittal line) to the motor cortex. The stimulus intensity was 80% of the patient's motor threshold intensity. Treatments were given for 20 minutes per day over 10 working days.

sham rTMS

Procedure

sham rTMS

Primary outcomes

  1. Tower of London

    Time frame: Inclusion, 15th day, 30th day and 3rd month

Secondary outcomes

  1. Balloon Analog Risk Task

    Time frame: Inclusion, 15th day, 30th day and 3rd month

  2. Micro-World Test

    Time frame: Inclusion, 15th day and 3rd month

  3. Borderline Personality Disorder Severity Index

    Time frame: Pre-inclusion, 30th day and 3rd month

  4. Symptom Check List - 90

    Time frame: Inclusion, 15th day, 30th day and 3rd month

  5. Barratt Impulsivity Scale

    Time frame: Inclusion and 3rd month

  6. Global Assessment Scale

    Time frame: Inclusion and 3rd month

Sponsors and collaborators

Lead sponsor

University Hospital, Toulouse

Other

Registry information

Official study title

Effect of Repetitive Transcranial Magnetic Stimulation (rTMS) on Borderline Personality Disorder (BPD)

Acronym: SiMaT-B

Important dates

Study start
2010
Primary completion
2011
Study completion
2012
First posted
Feb 26, 2010
Registry last updated
May 11, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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